The Library
Antimetastatic action of Pentoxifylline, a methyl xanthine derivative, through its effect on PKC Mediated integrin transport in B16F10 melanoma cells
Tools
Tools
Tools
Ratheesh, Aparna, Meenakashi, Jain and Gudea, Rajiv P. (2010) Antimetastatic action of Pentoxifylline, a methyl xanthine derivative, through its effect on PKC Mediated integrin transport in B16F10 melanoma cells. World Journal of Oncology, 1 (5). pp. 194-203. doi:10.4021/wjon252e
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.4021/wjon252e
Abstract
Integrins are adhesion molecules known to regulate cellular processes like adhesion, migration and proliferation. At the same time role of integrin in progress of cancer metastasis is well established, increased integrin expression is reported to be linked to high metastasis potential of cells. Pentoxifylline a methyl xanthine derivative is a potent antimetastatic agent. Studies on the mechanism of inhibition of lung homing of B16F10 melanoma cells by PTX shows that it can inhibit cell- Extracellular Matrix adhesion, cell surface integrin expression as well as Protein kinase C activity. Previous study from our laboratory have shown PTX treatment can selectively inhibit the cell surface expression of α5 integrin in B16F10 cells without affecting its total cellular protein levels. Numerous studies have documented that differences in surface expression and distribution of integrins affects metastasis. The purpose of present study is to observe the effect of PTX on cellular distribution/ redistribution of integrins and to study the underlying molecular mechanism of PTX action.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
||||||
| Journal or Publication Title: | World Journal of Oncology | ||||||
| Publisher: | Elmer Press Inc. | ||||||
| ISSN: | 1920-4531 | ||||||
| Official Date: | 2010 | ||||||
| Dates: |
|
||||||
| Volume: | 1 | ||||||
| Number: | 5 | ||||||
| Page Range: | pp. 194-203 | ||||||
| DOI: | 10.4021/wjon252e | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
