The influence of dithiothreitol on DNA radiolysis in frozen aqueous solution: an EPR study
UNSPECIFIED. (2002) The influence of dithiothreitol on DNA radiolysis in frozen aqueous solution: an EPR study. RADIATION PHYSICS AND CHEMISTRY, 64 (2). pp. 107-113. ISSN 0969-806XFull text not available from this repository.
The effect of a thiol, dithiothreitol (DTT), on DNA radiolysis at cryogenic temperatures was investigated by the EPR method. Dithiothreitol repairs up to 30% of DNA radicals, but an increase in the thiol concentration above 10 mM, even up to 1000 mM, does not further enhance the overall level of the repair process. The transfers of paramagnetic centres from both the guanine radical cation. and the allyl radical of thymine, to thiol were observed, while products generated via the reductive pathway remained unaffected. (C) 2002 Elsevier Science Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QC Physics
|Journal or Publication Title:||RADIATION PHYSICS AND CHEMISTRY|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Official Date:||May 2002|
|Number of Pages:||7|
|Page Range:||pp. 107-113|
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