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Synthesis and cycloaddition reactions of derivatives of strained alkynes derived from 2,2’-dihydroxy-1,1’-biaryls
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Mistry, Anish, Knighton, Richard C., Forshaw, Sam, Dualeh, Zakaria, Parker, Jeremy S. and Wills, Martin (2018) Synthesis and cycloaddition reactions of derivatives of strained alkynes derived from 2,2’-dihydroxy-1,1’-biaryls. Organic and Biomolecular Chemistry, 16 (46). 8965-8975 . doi:10.1039/C8OB01768A ISSN 1477-0520.
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Official URL: https://doi.org/10.1039/C8OB01768A
Abstract
A series of strained alkynes, based on the 2,2’-dihydroxy-1,1’-biaryl structure, were prepared in a short sequence from readily-available starting materials. These compounds can be readily converted into further derivatives including examples containing fluorescent groups with potential for use as labelling reagents. The alkynes are able to react in cycloadditions with a range of azides without the requirement for a copper catalyst, in clean reactions with no observable side reactions.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Alkynes -- Synthesis, Ring formation (Chemistry) | |||||||||||||||||||||
Journal or Publication Title: | Organic and Biomolecular Chemistry | |||||||||||||||||||||
Publisher: | RSC | |||||||||||||||||||||
ISSN: | 1477-0520 | |||||||||||||||||||||
Official Date: | 14 December 2018 | |||||||||||||||||||||
Dates: |
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Volume: | 16 | |||||||||||||||||||||
Number: | 46 | |||||||||||||||||||||
Page Range: | 8965-8975 | |||||||||||||||||||||
DOI: | 10.1039/C8OB01768A | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 12 October 2018 | |||||||||||||||||||||
Date of first compliant Open Access: | 19 November 2018 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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