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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
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UNSPECIFIED (2002) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. CELL, 109 (3). pp. 321-334. ISSN 0092-8674
Full text not available from this repository.Abstract
To explore the role of c-Myc in carcinogenesis, we have developed a reversible transgenic model of pancreatic beta cell oncogenesis using a switchable form of the c-Myc protein. Activation of c-Myc in adult, mature beta cells induces uniform beta cell proliferation but is accompanied by overwhelming apoptosis that rapidly erodes beta cell mass. Thus, the oncogenic potential of c-Myc in beta cells is masked by apoptosis. Upon suppression of c-Myc-induced beta cell apoptosis by coexpression Of Bcl-X-L, c-Myc triggers rapid and uniform progression into angiogenic, invasive tumors. Subsequent c-Myc deactivation induces rapid regression associated with vascular degeneration and beta cell apoptosis. Our data indicate that highly complex neoplastic lesions can be both induced and maintained in vivo by a simple combination of two interlocking molecular lesions.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | CELL |
| Publisher: | CELL PRESS |
| ISSN: | 0092-8674 |
| Date: | 3 May 2002 |
| Volume: | 109 |
| Number: | 3 |
| Number of Pages: | 14 |
| Page Range: | pp. 321-334 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/10996 |
Data sourced from Thomson Reuters' Web of Knowledge
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