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Advances in understanding the mechanism of action of the auxin permease AUX1

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Singh, Gaurav, Retzer, Katarzyna, Vosolsobě, Stanislav and Napier, R. (Richard) (2018) Advances in understanding the mechanism of action of the auxin permease AUX1. International Journal of Molecular Sciences, 19 (11). 3391. doi:10.3390/ijms19113391 ISSN 1422-0067.

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Official URL: https://doi.org/10.3390/ijms19113391

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Abstract

In over 40 years of research on the cellular uptake of auxin it is somewhat chastening that we have elabourated little on the original kinetic descriptions of auxin uptake by plant cells made by Rubery and Sheldrake in 1974. Every aspect of that seminal work has been investigated in detail and the uptake activity they measured is now known to be attributed to the AUX1/LAX family of permeases. Recent pharmacological studies have defined the substrate specificity of AUX1, biochemical studies have evaluated its permeability to auxin in plant cell membranes, and rigourous kinetic studies have confirmed the affinity of AUX1 for IAA and synthetic auxins. Advances in genome sequencing have provided a rich resource for informatic analysis of the ancestry of AUX1 and the LAX proteins and, along with models of topology, suggest mechanistic links to families of eukaryotic proton co-transporters for which crystal structures have been presented. The insights gained from all the accumulated research reflect the brilliance of Rubery and Sheldrake’s early work, but recent biochemical analyses are starting to advance further our understanding of this vitally important family of auxin transport proteins.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Auxin, Plant cells and tissues
Journal or Publication Title: International Journal of Molecular Sciences
Publisher: M D P I AG
ISSN: 1422-0067
Official Date: 30 October 2018
Dates:
DateEvent
30 October 2018Published
24 October 2018Accepted
Volume: 19
Number: 11
Article Number: 3391
DOI: 10.3390/ijms19113391
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 25 October 2018
Date of first compliant Open Access: 2 November 2018
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
CZ.02.1.01/ 0.0/0.0/16_019/0000738 [ERDF] European Regional Development Fundhttp://dx.doi.org/10.13039/501100008530
PUI no. LO1417[ERDF] European Regional Development Fundhttp://dx.doi.org/10.13039/501100008530
16–10948SGrantová Agentura České Republikyhttp://dx.doi.org/10.13039/501100001824
MSM200381701Akademie věd České Republikyhttp://dx.doi.org/10.13039/501100004240
SB/OS/PDF-336/2016-17 Science and Engineering Research Boardhttp://dx.doi.org/10.13039/501100001843
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