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Partial maintenance of organ-specific epigenetic marks during plant asexual reproduction leads to heritable phenotypic variation

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Wibowo, Anjar, Becker, Claude, Durr, Julius, Price, Jonathan, Spaepen, Stijn, Hilton, Sally, Putra, Hadi, Papareddy, Ranjith, Saintain, Quentin, Harvey, Sarah, Bending, G. D., Schulze-Lefert, Paul, Weigel, Detlef and Gutierrez-Marcos, José F. (2018) Partial maintenance of organ-specific epigenetic marks during plant asexual reproduction leads to heritable phenotypic variation. Proceedings of the National Academy of Sciences of the United States of America, 115 (39). E9145-E9152. doi:10.1073/pnas.1805371115

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Official URL: http://dx.doi.org/10.1073/pnas.1805371115

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Abstract

While clonally propagated individuals should share identical genomes, there is often substantial phenotypic variation among them. Both genetic and epigenetic modifications induced during regeneration have been associated with this phenomenon. Here we investigated the fate of the epigenome after asexual propagation by generating clonal individuals from differentiated somatic cells through the manipulation of a zygotic transcription factor. We found that phenotypic novelty in clonal progeny was linked to epigenetic imprints that reflect the organ used for regeneration. Some of these organ-specific imprints can be maintained during the cloning process and subsequent rounds of meiosis. Our findings are fundamental for understanding the significance of epigenetic variability arising from asexual reproduction and have significant implications for future biotechnological applications.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Reproduction, Asexual, Arabidopsis thaliana -- Reproduction
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Publisher: National Academy of Sciences
ISSN: 0027-8424
Official Date: 10 September 2018
Dates:
DateEvent
10 September 2018Published
Volume: 115
Number: 39
Page Range: E9145-E9152
DOI: 10.1073/pnas.1805371115
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
751204- H2020-MSCA-IF-2016European Research Council http://viaf.org/viaf/130022607
AdG IMMUNEMESISEuropean Research Councilhttp://viaf.org/viaf/130022607
SPP1529 Progra[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
UNSPECIFIEDMax-Planck-Gesellschafthttp://dx.doi.org/10.13039/501100004189
AdG ROOTMICROBIOTAEuropean Research Councilhttp://viaf.org/viaf/130022607
UNSPECIFIEDCluster of Excellence on Plant ScienceUNSPECIFIED
BB/L025892/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/L003023/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/N005279/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/N00194X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/P02601X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

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