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Partial maintenance of organ-specific epigenetic marks during plant asexual reproduction leads to heritable phenotypic variation
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Wibowo, Anjar, Becker, Claude, Durr, Julius, Price, Jonathan, Spaepen, Stijn, Hilton, Sally, Putra, Hadi, Papareddy, Ranjith, Saintain, Quentin, Harvey, Sarah, Bending, G. D., Schulze-Lefert, Paul, Weigel, Detlef and Gutierrez-Marcos, José F. (2018) Partial maintenance of organ-specific epigenetic marks during plant asexual reproduction leads to heritable phenotypic variation. Proceedings of the National Academy of Sciences of the United States of America, 115 (39). E9145-E9152. doi:10.1073/pnas.1805371115
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Official URL: http://dx.doi.org/10.1073/pnas.1805371115
Abstract
While clonally propagated individuals should share identical genomes, there is often substantial phenotypic variation among them. Both genetic and epigenetic modifications induced during regeneration have been associated with this phenomenon. Here we investigated the fate of the epigenome after asexual propagation by generating clonal individuals from differentiated somatic cells through the manipulation of a zygotic transcription factor. We found that phenotypic novelty in clonal progeny was linked to epigenetic imprints that reflect the organ used for regeneration. Some of these organ-specific imprints can be maintained during the cloning process and subsequent rounds of meiosis. Our findings are fundamental for understanding the significance of epigenetic variability arising from asexual reproduction and have significant implications for future biotechnological applications.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QK Botany |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Reproduction, Asexual, Arabidopsis thaliana -- Reproduction | ||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Proceedings of the National Academy of Sciences of the United States of America | ||||||||||||||||||||||||||||||||||||
| Publisher: | National Academy of Sciences | ||||||||||||||||||||||||||||||||||||
| ISSN: | 0027-8424 | ||||||||||||||||||||||||||||||||||||
| Official Date: | 10 September 2018 | ||||||||||||||||||||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 25 October 2018 | ||||||||||||||||||||||||||||||||||||
| Volume: | 115 | ||||||||||||||||||||||||||||||||||||
| Number: | 39 | ||||||||||||||||||||||||||||||||||||
| Page Range: | E9145-E9152 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.1073/pnas.1805371115 | ||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||||||||||||||||||||
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