The Library
MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
Tools
Tools
Tools
Li, Xuan, Thome, Sarah, Ma, Xiaodan, Amrute-Nayak, Mamta, Finigan, Alison, Kitt, Lauren, Masters, Leanne, James, John R., Shi, Yuguang, Meng, Guoyu and Mallat, Ziad (2017) MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nature Communications, 8 . 15986. doi:10.1038/ncomms15986 ISSN 2041-1723.
|
PDF
WRAP-MARK4-regulates-NLPR3-positioning-inflammasone-activation-James.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2441Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/ncomms15986
Abstract
Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including cardiovascular and Alzheimer’s disease. Here we show that microtubule-affinity regulating kinase 4 (MARK4) binds to NLRP3 and drives it to the microtubule-organizing centre, enabling the formation of one large inflammasome speck complex within a single cell. MARK4 knockdown or knockout, or disruption of MARK4-NLRP3 interaction, impairs NLRP3 spatial arrangement and limits inflammasome activation. Our results demonstrate how an evolutionarily conserved protein involved in the regulation of microtubule dynamics orchestrates NLRP3 inflammasome activation by controlling its transport to optimal activation sites, and identify a targetable function for MARK4 in the control of innate immunity.
| Item Type: | Journal Article | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
|||||||||||||||
| Library of Congress Subject Headings (LCSH): | Inflammation -- Immunological aspects, Protein kinases, Microtubules | |||||||||||||||
| Journal or Publication Title: | Nature Communications | |||||||||||||||
| Publisher: | Nature Publishing Group | |||||||||||||||
| ISSN: | 2041-1723 | |||||||||||||||
| Official Date: | 28 June 2017 | |||||||||||||||
| Dates: |
|
|||||||||||||||
| Volume: | 8 | |||||||||||||||
| Article Number: | 15986 | |||||||||||||||
| DOI: | 10.1038/ncomms15986 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 26 October 2018 | |||||||||||||||
| Date of first compliant Open Access: | 29 October 2018 | |||||||||||||||
| RIOXX Funder/Project Grant: |
|
|||||||||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
