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Intramolecular DNA coiling mediated by metallosupramolecular cylinders: Differential binding of P and M helical enantiomers
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UNSPECIFIED. (2002) Intramolecular DNA coiling mediated by metallosupramolecular cylinders: Differential binding of P and M helical enantiomers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99 (8). pp. 5069-5074. ISSN 0027-8424
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Official URL: http://dx.doi.org/10.1073/pnas.062634499
Abstract
We have designed a synthetic tetracationic metallo-supramolecular cylinder that targets the major groove of DNA with a binding constant in excess of 10(7) M-1 and induces DNA bending and intramolecular coiling. The two enantiomers of the helical molecule bind differently to DNA and have different structural effects. We report the characterization of the interactions by a range of biophysical techniques. The M helical cylinder binds to the major groove and induces dramatic intramolecular coiling. The DNA bending is less dramatic for the P enantiomer.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science |
| Journal or Publication Title: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
| Publisher: | NATL ACAD SCIENCES |
| ISSN: | 0027-8424 |
| Date: | 16 April 2002 |
| Volume: | 99 |
| Number: | 8 |
| Number of Pages: | 6 |
| Page Range: | pp. 5069-5074 |
| Identification Number: | 10.1073/pnas.062634499 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/11027 |
Data sourced from Thomson Reuters' Web of Knowledge
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