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PIN proteins perform a rate-limiting function in cellular auxin efflux
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(2006) PIN proteins perform a rate-limiting function in cellular auxin efflux. Science, 312 (5775). pp. 914-918. doi:10.1126/science.1123542 ISSN 0036-8075.
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Official URL: http://dx.doi.org/10.1126/science.1123542
Abstract
Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific pin-formed (PIN) proteins and several phosphoglycoprotein (PGP) transporters are crucial factors in auxin transport–related development, yet the molecular function of PINs remains unknown. Here, we show that PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. Conditional gain-of-function alleles and quantitative measurements of auxin accumulation in Arabidopsis and tobacco cultured cells revealed that the action of PINs in auxin efflux is distinct from PGP, rate-limiting, specific to auxins, and sensitive to auxin transport inhibitors. This suggests a direct involvement of PINs in catalyzing cellular auxin efflux.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Science | ||||
Publisher: | American Association for the Advancement of Science | ||||
ISSN: | 0036-8075 | ||||
Official Date: | May 2006 | ||||
Dates: |
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Volume: | 312 | ||||
Number: | 5775 | ||||
Page Range: | pp. 914-918 | ||||
DOI: | 10.1126/science.1123542 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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