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Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans
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Tomás, Ruben M. F., Martyn, Benjamin T., Bailey, Trisha L. and Gibson, Matthew I. (2018) Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans. ACS Macro Letters, 2018 (7). pp. 1289-1294. doi:10.1021/acsmacrolett.8b00675 ISSN 2161-1653.
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WRAP-engineering-cell-surfaces-covalent-grafting-synthetic-polymers-metabolically-labeled-glycans-Gibson-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (6Mb) | Preview |
Official URL: http://dx.doi.org/10.1021/acsmacrolett.8b00675
Abstract
Re-engineering mammalian cell surfaces enables modulation of their phenotype, function, and interactions with external markers and may find application in cell-based therapies. Here we use metabolic glycan labeling to install azido groups onto the cell surface, which can act as anchor points to enable rapid, simple, and robust “click” functionalization by the addition of a polymer bearing orthogonally reactive functionality. Using this strategy, new cell surface functionality was introduced by using telechelic polymers with fluorescence or biotin termini, demonstrating that recruitment of biomacromolecules is possible. This approach may enable the attachment of payloads and modulation of cell function and fate, as well as providing a tool to interface synthetic polymers with biological systems.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Cell membranes, Polymers, Cellular therapy | ||||||||||||||||||
| Journal or Publication Title: | ACS Macro Letters | ||||||||||||||||||
| Publisher: | American Chemical Society | ||||||||||||||||||
| ISSN: | 2161-1653 | ||||||||||||||||||
| Official Date: | 10 October 2018 | ||||||||||||||||||
| Dates: |
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| Volume: | 2018 | ||||||||||||||||||
| Number: | 7 | ||||||||||||||||||
| Page Range: | pp. 1289-1294 | ||||||||||||||||||
| DOI: | 10.1021/acsmacrolett.8b00675 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
| Date of first compliant deposit: | 6 November 2018 | ||||||||||||||||||
| Date of first compliant Open Access: | 7 November 2018 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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