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Photoactivatable cell-selective dinuclear trans diazido platinum(IV) anticancer prodrugs
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Shi, Huayun, Romero-Canelón, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, Venkatesh, Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, P. J. (2018) Photoactivatable cell-selective dinuclear trans diazido platinum(IV) anticancer prodrugs. Inorganic Chemistry, 57 (22). pp. 14409-14420. doi:10.1021/acs.inorgchem.8b02599 ISSN 0020-1669.
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WRAP-photoactivatable-cell-selective-dinuclear-trans-diazidoplatinum-IV-anticancer-prodrugs-Shi-Sadler-2018.pdf - Accepted Version - Requires a PDF viewer. Download (2862Kb) | Preview |
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WRAP-110594-Supporting_information_SI_Photoactivatable Cell-selective Dinuclear Trans Diazido Plati-num(IV) Anticancer Prodrugs_v2.pdf - Supplemental Material - Requires a PDF viewer. Download (916Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acs.inorgchem.8b02599
Abstract
Novel all-trans dinuclear PtIV complexes bridged by a dicarboxylate linker, highly stable in the dark, generate azidyl and hydroxyl radicals upon irradiation with blue light. They are photocytotoxic to human cancer cells, whereas cisplatin was inactive under these conditions and more photoactive toward cisplatin-resistant ovarian cancer cells compared to wild-type cells. Remarkably, the dinuclear complexes were relatively nontoxic toward normal human cells. Cell cycle and DNA binding experiments suggested that DNA is a target.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Antineoplastic agents -- Development, Platinum compounds -- Therapeutic use, Cisplatin, Azides, Photochemistry | |||||||||||||||||||||||||||
Journal or Publication Title: | Inorganic Chemistry | |||||||||||||||||||||||||||
Publisher: | American Chemical Society | |||||||||||||||||||||||||||
ISSN: | 0020-1669 | |||||||||||||||||||||||||||
Official Date: | 19 November 2018 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 57 | |||||||||||||||||||||||||||
Number: | 22 | |||||||||||||||||||||||||||
Page Range: | pp. 14409-14420 | |||||||||||||||||||||||||||
DOI: | 10.1021/acs.inorgchem.8b02599 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Reuse Statement (publisher, data, author rights): | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/v10.1021/acs.inorgchem.8b02599. | |||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||
Date of first compliant deposit: | 12 November 2018 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 26 October 2019 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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