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Synthesis and in vitro enzyme activity of an oxa analogue of azi-DAP
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UNSPECIFIED. (2002) Synthesis and in vitro enzyme activity of an oxa analogue of azi-DAP. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (8). pp. 1029-1035. ISSN 1472-7781
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Official URL: http://dx.doi.org/10.1039/b201727j
Abstract
The synthesis of a novel epoxide inhibitor 6 of meso-DAP epimerase was achieved. A new and convenient assay for meso-DAP epimerase was devised which is a considerable improvement on previously reported assay methods. This assay was used to determine the inhibitory properties of 6. The epoxide 6 shows limited competitive inhibition vs. meso-DAP epimerase, but clear time dependent inhibition indicative of the expected covalent attachment at the active site. Epoxide 6, although an effective inhibitor of meso-DAP epimerase, was unstable at pH 7.3 in aqueous buffer, being hydrolysed to the corresponding diol.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Journal or Publication Title: | JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 |
| Publisher: | ROYAL SOC CHEMISTRY |
| ISSN: | 1472-7781 |
| Date: | 2002 |
| Number: | 8 |
| Number of Pages: | 7 |
| Page Range: | pp. 1029-1035 |
| Identification Number: | 10.1039/b201727j |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/11062 |
Data sourced from Thomson Reuters' Web of Knowledge
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