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A role for 3′-O-β-D-ribofuranosyladenosine in altering plant immunity
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Drenichev, Mikhail S., Bennett, Mark, Novikov, Roman A., Mansfield, John, Smirnoff, Nick, Grant, Murray R. and Mikhailov, Sergey N. (2019) A role for 3′-O-β-D-ribofuranosyladenosine in altering plant immunity. Phytochemistry Letters, 157 . pp. 128-134. doi:10.1016/j.phytochem.2018.10.016
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WRAP-role-ribofuranosyladenosine-plant-immunity-Grant-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (750Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.phytochem.2018.10.016
Abstract
Our understanding of how, and the extent to which, phytopathogens reconfigure host metabolic pathways to enhance virulence is remarkably limited. Here we investigate the dynamics of the natural disaccharide nucleoside, 3′-O-β-D-ribofuranosyladenosine, in leaves of Arabidopsis thaliana infected with virulent Pseudomonas syringae pv. tomato strain DC3000. 3′-O-β-D-ribofuranosyladenosine is a plant derived molecule that rapidly accumulates following delivery of P. syringae type III effectors to represent a major component of the infected leaf metabolome. We report the first synthesis of 3′-O-β-D-ribofuranosyladenosine using a method involving the condensation of a small excess of 1-O-acetyl-2,3,5-three-O-benzoyl-β-ribofuranose activated with tin tetrachloride with 2′,5′-di-O-tert-butyldimethylsilyladenosine in 1,2-dichloroethane with further removal of silyl and benzoyl protecting groups. Interestingly, application of synthetic 3′-O-β-D-ribofuranosyladenosine did not affect either bacterial multiplication or infection dynamics suggesting a major reconfiguration of metabolism during pathogenesis and a heavy metabolic burden on the infected plant.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QR Microbiology S Agriculture > SB Plant culture |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Plants -- Disease and pest resistance, Plants -- Metabolism, Phytopathogenic microorganisms | ||||||||||||
| Journal or Publication Title: | Phytochemistry Letters | ||||||||||||
| Publisher: | Elsevier BV | ||||||||||||
| ISSN: | 1874-3900 | ||||||||||||
| Official Date: | January 2019 | ||||||||||||
| Dates: |
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| Volume: | 157 | ||||||||||||
| Page Range: | pp. 128-134 | ||||||||||||
| DOI: | 10.1016/j.phytochem.2018.10.016 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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