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Coupling electron capture dissociation and the modified Kendrick mass defect for sequencing of a poly(2-ethyl-2-oxazoline) polymer
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Morgan, Tomos E., Ellacott, Sean H., Wootton, Christopher, Barrow, Mark P., Bristow, Anthony W. T., Perrier, Sébastien and O'Connor, Peter B. (2018) Coupling electron capture dissociation and the modified Kendrick mass defect for sequencing of a poly(2-ethyl-2-oxazoline) polymer. Analytical Chemistry, 90 (19). pp. 11710-11715. doi:10.1021/acs.analchem.8b03591
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WRAP-coupling-electron-capture-Kendrick-mass-defect-polymer-Morgan-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1410Kb) | Preview |
Official URL: https://doi.org/10.1021/acs.analchem.8b03591
Abstract
With increasing focus on the structural elucidation of polymers, advanced tandem mass spectrometry techniques will play a crucial role in the characterization of these compounds. In this contribution, synthesis and analysis of methyl initiated and xan-thate terminated poly (2-ethyl-2-oxazoline) using Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry was achieved. Electron capture dissociation (ECD) produced full end group characterization as well as back bone fragmentation including complete sequence coverage of the polymer. A method of fragment ion characterization is also presented with the use of the high resolution modified Kendrick mass defect plots as a means of grouping fragments from the same fragmentation pathways together. This type of data processing is applicable to all tandem mass spectrometry techniques for polymer analysis but is made more effective with high mass accuracy methods. ECD FT-ICR MS demonstrates its promising role as a structural characterization technique for polyoxazoline species.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||
| Divisions: | Faculty of Science > Chemistry | |||||||||
| Library of Congress Subject Headings (LCSH): | Tandem mass spectrometry, Polymers -- Structure, Ion cyclotron resonance spectrometry, Fourier transform spectroscopy, Electrons -- Capture, Oxazoles | |||||||||
| Journal or Publication Title: | Analytical Chemistry | |||||||||
| Publisher: | American Chemical Society | |||||||||
| ISSN: | 0003-2700 | |||||||||
| Official Date: | 2 October 2018 | |||||||||
| Dates: |
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| Date of first compliant deposit: | 14 November 2018 | |||||||||
| Volume: | 90 | |||||||||
| Number: | 19 | |||||||||
| Page Range: | pp. 11710-11715 | |||||||||
| DOI: | 10.1021/acs.analchem.8b03591 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Publisher Statement: | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].” | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Copyright Holders: | American Chemical Society | |||||||||
| RIOXX Funder/Project Grant: |
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