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Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators
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Fumeaux, Coralie, Radhakrishnan, Sunish Kumar, Ardissone, Silvia, Théraulaz, Laurence, Frandi, Antonio, Martins, Daniel, Nesper, Jutta, Abel, Sören, Jenal, Urs and Viollier, Patrick H. (2014) Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators. Nature Communications, 5 (1). 4081 . doi:10.1038/ncomms5081 ISSN 2041-1723.
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Official URL: http://dx.doi.org/10.1038/ncomms5081
Abstract
Zinc-finger domain transcriptional regulators regulate a myriad of functions in eukaryotes. Interestingly, ancestral versions (MucR) from Alpha-proteobacteria control bacterial virulence/symbiosis. Whether virulence regulators can also control cell cycle transcription is unknown. Here we report that MucR proteins implement a hitherto elusive primordial S→G1 transcriptional switch. After charting G1-specific promoters in the cell cycle model Caulobacter crescentus by comparative ChIP-seq, we use one such promoter as genetic proxy to unearth two MucR paralogs, MucR1/2, as constituents of a quadripartite and homeostatic regulatory module directing the S→G1 transcriptional switch. Surprisingly, MucR orthologues that regulate virulence and symbiosis gene transcription in Brucella, Agrobacterium or Sinorhizobium support this S→G1 switch in Caulobacter. Pan-genomic ChIP-seq analyses in Sinorhizobium and Caulobacter show that this module indeed targets orthologous genes. We propose that MucR proteins and possibly other virulence regulators primarily control bacterial cell cycle (G1-phase) transcription, rendering expression of target (virulence) genes periodic and in tune with the cell cycle.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Nature Communications | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 2041-1723 | ||||
Official Date: | 18 June 2014 | ||||
Dates: |
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Volume: | 5 | ||||
Number: | 1 | ||||
Article Number: | 4081 | ||||
DOI: | 10.1038/ncomms5081 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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