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In-phase oscillation of global regulons is orchestrated by a pole-specific organizer
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Janakiraman, Balaganesh, Mignolet, Johann, Narayanan, Sharath, Viollier, Patrick H. and Radhakrishnan, Sunish Kumar (2016) In-phase oscillation of global regulons is orchestrated by a pole-specific organizer. Proceedings of the National Academy of Sciences of the United States of America, 113 (44). pp. 12550-12555. doi:10.1073/pnas.1610723113 ISSN 0027-8424.
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Official URL: http://dx.doi.org/10.1073/pnas.1610723113
Abstract
Although several studies have pointed towards the importance of the sigma factor, σ54, in regulating virulence, biofilm formation, and cell cycle control in α-proteobacteria, knowledge on its activators and their regulation is incomplete. In this study, we demonstrate that the activity of a highly conserved σ54-activator, TacA, is spatiotemporally coordinated with that of the master cell cycle transcriptional regulator A (CtrA) in Caulobacter crescentus. Remarkably, we find that the polar organizer/morphogen, SpmX, governs the in-phase oscillation of CtrA, via the cell fate-determining kinase DivJ, and TacA via a newly identified and conserved determinant, SpmY, which is recruited to the poles through SpmX. Most importantly, we show that the DUF2336 domain of SpmY is functionally conserved among the α-proteobacteria, revealing a possibly conserved mechanism to regulate TacA.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Proceedings of the National Academy of Sciences of the United States of America | ||||
Publisher: | National Academy of Sciences | ||||
ISSN: | 0027-8424 | ||||
Official Date: | 16 September 2016 | ||||
Dates: |
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Volume: | 113 | ||||
Number: | 44 | ||||
Page Range: | pp. 12550-12555 | ||||
DOI: | 10.1073/pnas.1610723113 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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