Kamau, E., Onyango, C. O., Otieno, G. P., Kiyuka, P. K., Agoti, C. N., Medley, G. F., Cane, P. A., Nokes, D. James and Munywoki, P. K. (2019) An intensive, active surveillance reveals continuous invasion and high diversity of rhinovirus in households. Journal of Infectious Diseases, 219 (7). pp. 1049-1057. doi:10.1093/infdis/jiy621

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Abstract

We report on infection patterns in 5 households (78 participants) delineating the natural history of human rhinovirus (HRV). Nasopharyngeal collections were obtained every 3–4 days irrespective of symptoms, over a 6-month period, with molecular screening for HRV and typing by sequencing VP4/VP2 junction. Overall, 311/3468 (8.9%) collections were HRV positive: 256 were classified into 3 species: 104 (40.6%) HRV-A; 14 (5.5%) HRV-B, and 138 (53.9%) HRV-C. Twenty-six known HRV types (13 HRV-A, 3 HRV-B, and 10 HRV-C) were identified (A75, C1, and C35 being most frequent). We observed continuous invasion and temporal clustering of HRV types in households (range 5–13 over 6 months). Intrahousehold transmission was independent of clinical status but influenced by age. Most (89.0%) of HRV infection episodes were limited to <14 days. Individual repeat infections were frequent (range 1–7 over 6 months), decreasing with age, and almost invariably heterotypic, indicative of lasting type-specific immunity and low cross-type protection.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Rhinoviruses , Rhinoviruses -- Transmission -- Kenya
Journal or Publication Title:	Journal of Infectious Diseases
Publisher:	Oxford University Press
ISSN:	0022-1899
Official Date:	1 April 2019
Dates:	Date Event 1 April 2019 Published 20 December 2018 Available 21 November 2018 Accepted
Date of first compliant deposit:	21 November 2018
Volume:	219
Number:	7
Page Range:	pp. 1049-1057
DOI:	10.1093/infdis/jiy621
Status:	Peer Reviewed
Publication Status:	Published
Publisher Statement:	This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Infectious Diseases following peer review. The version of record Everlyn Kamau, Clayton O Onyango, Grieven P Otieno, Patience K Kiyuka, Charles N Agoti, Graham F Medley, Patricia A Cane, D James Nokes, Patrick K Munywoki, An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households, The Journal of Infectious Diseases, Volume 219, Issue 7, 1 April 2019, Pages 1049–1057, https://doi.org/10.1093/infdis/jiy621, is available online at: https://doi.org/10.1093/infdis/jiy621
Access rights to Published version:	Restricted or Subscription Access
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID 090853 Wellcome Trust http://dx.doi.org/10.13039/100010269 102975 Wellcome Trust http://dx.doi.org/10.13039/100010269 203077 Wellcome Trust http://dx.doi.org/10.13039/100010269
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