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Head growth and intelligence from birth to adulthood in very preterm and term born individuals
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Jaekel, Julia, Sorg, Christian, Baeuml, Josef, Bartmann, Peter and Wolke, Dieter (2019) Head growth and intelligence from birth to adulthood in very preterm and term born individuals. Journal of the International Neuropsychological Society, 25 (1). pp. 48-56. doi:10.1017/S135561771800084X
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Official URL: http://dx.doi.org/10.1017/S135561771800084X
Abstract
Objectives: The aim of this study was to investigate the effects of infant and toddler head growth on intelligence scores from early childhood to adulthood in very preterm (<32 weeks gestational age; VP) and/or very low birth weight (<1500 g; VLBW) and term born individuals. Methods: 203 VP/VLBW and 198 term comparisons were studied from birth to adulthood as part of the prospective geographically defined Bavarian Longitudinal Study (BLS). Head circumference was assessed at birth; 5, 20 months; and 4 years of age. Intelligence was assessed with standardized tests in childhood (6 and 8 years: K-ABC) and at 26 years (Wechsler Adult Intelligence Scale, WAIS). Structural equation modeling (SEM) was used to model the effect of head growth on IQ. Results: On average, VP/VLBW had lower head circumference at birth (27.61 cm vs. 35.11 cm, mean difference 7.49, 95% confidence interval [7.09–7.90]) and lower adult intelligence scores (88.98 vs. 102.54, mean difference 13.56 [10.59–16.53]) than term born comparison individuals. Head circumference at birth (e.g., total effect β=.48; p<.001 for adult IQ) and head growth in childhood predicted intelligence development from age 6 to 26 years in both VP/VLBW and term born individuals (70% of variance in adult IQ explained by full model). Effects of gestation and birth weight on intelligence were fully mediated by head circumference and growth. Conclusions: This longitudinal investigation from birth to adulthood indicates head growth as a proxy of brain development and intelligence. Repeated early head circumference assessment adds valuable information when screening for long-term neurocognitive risk. (JINS, 2019, 25, 48#x2013;56)
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RJ Pediatrics | |||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Premature infants -- Intelligence levels, Birth weight, Low, Head | |||||||||||||||
| Journal or Publication Title: | Journal of the International Neuropsychological Society | |||||||||||||||
| Publisher: | Cambridge University Press | |||||||||||||||
| ISSN: | 1355-6177 | |||||||||||||||
| Official Date: | January 2019 | |||||||||||||||
| Dates: |
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| Volume: | 25 | |||||||||||||||
| Number: | 1 | |||||||||||||||
| Page Range: | pp. 48-56 | |||||||||||||||
| DOI: | 10.1017/S135561771800084X | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Publisher Statement: | This article has been published in a revised form in Journal of the International Neuropsychological Society http://dx.doi.org/10.1017/S135561771800084X. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © The International Neuropsychological Society 2018 | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| Copyright Holders: | Copyright © The International Neuropsychological Society 2018 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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