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Head growth and intelligence from birth to adulthood in very preterm and term born individuals
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Jaekel, Julia, Sorg, Christian, Baeuml, Josef, Bartmann, Peter and Wolke, Dieter (2018) Head growth and intelligence from birth to adulthood in very preterm and term born individuals. Journal of the International Neuropsychological Society . pp. 1-9. doi:10.1017/S135561771800084X (In Press)
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Official URL: http://dx.doi.org/10.1017/S135561771800084X
Abstract
Objectives
The aim of this study was to investigate the effects of infant and toddler head growth on intelligence scores from early childhood to adulthood in very preterm (<32 weeks gestational age; VP) and/or very low birth weight (<1500 g; VLBW) and term born individuals.
Methods
203 VP/VLBW and 198 term comparisons were studied from birth to adulthood as part of the prospective geographically defined Bavarian Longitudinal Study (BLS). Head circumference was assessed at birth; 5, 20 months; and 4 years of age. Intelligence was assessed with standardized tests in childhood (6 and 8 years: K-ABC) and at 26 years (Wechsler Adult Intelligence Scale, WAIS). Structural equation modeling (SEM) was used to model the effect of head growth on IQ. Results: On average, VP/VLBW had lower head circumference at birth (27.61 cm vs. 35.11 cm, mean difference 7.49, 95% confidence interval [7.09–7.90]) and lower adult intelligence scores (88.98 vs. 102.54, mean difference 13.56 [10.59–16.53]) than term born comparison individuals. Head circumference at birth (e.g., total effect β=.48; p<.001 for adult IQ) and head growth in childhood predicted intelligence development from age 6 to 26 years in both VP/VLBW and term born individuals (70% of variance in adult IQ explained by full model). Effects of gestation and birth weight on intelligence were fully mediated by head circumference and growth.
Conclusions
This longitudinal investigation from birth to adulthood indicates head growth as a proxy of brain development and intelligence. Repeated early head circumference assessment adds valuable information when screening for long-term neurocognitive risk. (JINS, 2018, 00, 1–9)
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RJ Pediatrics | |||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Premature infants -- Intelligence levels, Birth weight, Low, Head | |||||||||||||||
| Journal or Publication Title: | Journal of the International Neuropsychological Society | |||||||||||||||
| Publisher: | Cambridge University Press | |||||||||||||||
| ISSN: | 1355-6177 | |||||||||||||||
| Official Date: | 14 November 2018 | |||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 22 November 2018 | |||||||||||||||
| Page Range: | pp. 1-9 | |||||||||||||||
| DOI: | 10.1017/S135561771800084X | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | In Press | |||||||||||||||
| Publisher Statement: | This article has been published in a revised form in Journal of the International Neuropsychological Society http://dx.doi.org/10.1017/S135561771800084X. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © The International Neuropsychological Society 2018 | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| RIOXX Funder/Project Grant: |
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