Martyn, Benjamin T., Biggs, Caroline I. and Gibson, Matthew I. (2019) Comparison of systematically functionalized heterogeneous and homogenous glycopolymers as toxin inhibitors. Journal of Polymer Science Part A: Polymer Chemistry, 57 (1). pp. 40-47. doi:10.1002/pola.29279 ISSN 0887-624X.

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Abstract

Multivalent glycosylated polymers and particles display enhanced binding affinity toward lectins compared to individual glycans. The design of glycopolymers with selectivity toward pathogen‐associated lectins (toxins) for sensing or in antiadhesion therapy is complicated due to lectins having promiscuous binding profiles and can be considered to be pattern recognition “readers,” with the capability to bind to several different glycans. Here, heterogeneous glycopolymers bearing variable densities of two different monosaccharides are synthesized by a three‐step postpolymerization modification approach, enabling systematic control over composition. It is found that heterogeneous polymers displayed increased inhibitory activity, compared to homogeneous polymers, against a RCA120 and the cholera toxin. This demonstrates that embracing heterogeneity in glycomaterials could result in improved performance or emergent properties. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Polymers, Biomedical materials, Carbohydrates, Lectins, Addition polymerization
Journal or Publication Title:	Journal of Polymer Science Part A: Polymer Chemistry
Publisher:	John Wiley & Sons Ltd.
ISSN:	0887-624X
Official Date:	2019
Dates:	Date Event 2019 Published 20 November 2018 Available 30 October 2018 Accepted
Volume:	57
Number:	1
Page Range:	pp. 40-47
DOI:	10.1002/pola.29279
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	28 November 2018
Date of first compliant Open Access:	28 November 2018
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID UNSPECIFIED European Research Council http://viaf.org/viaf/130022607 EP/M506679/1 [EPSRC] Engineering and Physical Sciences Research Council http://dx.doi.org/10.13039/501100000266 UNSPECIFIED University of Warwick http://dx.doi.org/10.13039/501100000741

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