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Comparison of systematically functionalized heterogeneous and homogenous glycopolymers as toxin inhibitors
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Martyn, Benjamin T., Biggs, Caroline I. and Gibson, Matthew I. (2018) Comparison of systematically functionalized heterogeneous and homogenous glycopolymers as toxin inhibitors. Journal of Polymer Science Part A: Polymer Chemistry . doi:10.1002/pola.29279 (In Press)
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Official URL: http://dx.doi.org/10.1002/pola.29279
Abstract
Multivalent glycosylated polymers and particles display enhanced binding affinity toward lectins compared to individual glycans. The design of glycopolymers with selectivity toward pathogen‐associated lectins (toxins) for sensing or in antiadhesion therapy is complicated due to lectins having promiscuous binding profiles and can be considered to be pattern recognition “readers,” with the capability to bind to several different glycans. Here, heterogeneous glycopolymers bearing variable densities of two different monosaccharides are synthesized by a three‐step postpolymerization modification approach, enabling systematic control over composition. It is found that heterogeneous polymers displayed increased inhibitory activity, compared to homogeneous polymers, against a RCA120 and the cholera toxin. This demonstrates that embracing heterogeneity in glycomaterials could result in improved performance or emergent properties. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QD Chemistry | ||||||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Polymers, Biomedical materials, Carbohydrates, Lectins, Addition polymerization | ||||||||||||
| Journal or Publication Title: | Journal of Polymer Science Part A: Polymer Chemistry | ||||||||||||
| Publisher: | John Wiley & Sons Ltd. | ||||||||||||
| ISSN: | 0887-624X | ||||||||||||
| Official Date: | 20 November 2018 | ||||||||||||
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| Date of first compliant deposit: | 28 November 2018 | ||||||||||||
| DOI: | 10.1002/pola.29279 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | In Press | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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