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Connection between circadian rhythms and neurodegenerative diseases

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Leng, Yue, Musiek, Erik S., Hu, Kun, Cappuccio, Francesco and Yaffe, Kristine (2019) Connection between circadian rhythms and neurodegenerative diseases. The Lancet Neurology, 18 (3). pp. 307-318. doi:10.1016/S1474-4422(18)30461-7 ISSN 1474-4422.

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Official URL: https://doi.org/10.1016/S1474-4422(18)30461-7

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Abstract

Increasingly circadian rhythms have been linked to age-related diseases. We provide an up-to- date review (2013-2018) of the association between circadian rhythm disruptions (CRD) and the most common types of neurodegenerative diseases, including Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease (PD). CRD differ according to type and severity of neurodegenerative diseases, and importantly, could occur early during the course of neurodegeneration as a prodrome. Evolving evidence also supports CRD as a potential risk factor for developing ADRD and PD, although confirmatory studies are needed. Proposed mechanistic pathways underlying this association include alterations in sleep, protein homeostasis, and immune and inflammatory function. While promising, more studies of CRD and treatment trials are needed to determine whether circadian interventions may prevent or delay the onset of neurodegenerative diseases. The study of circadian rhythms holds great promise for a role in the prevention and management of neurodegenerative diseases.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Nervous system -- Degeneration, Circadian rhythms
Journal or Publication Title: The Lancet Neurology
Publisher: The Lancet Publishing Group
ISSN: 1474-4422
Official Date: March 2019
Dates:
DateEvent
March 2019Published
16 November 2018Accepted
Volume: 18
Number: 3
Page Range: pp. 307-318
DOI: 10.1016/S1474-4422(18)30461-7
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 30 November 2018
Date of first compliant Open Access: 30 November 2018
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
1K99AG056598-01National Institute on Aginghttp://dx.doi.org/10.13039/100000049
R01AG054517National Institute on Aginghttp://dx.doi.org/10.13039/100000049
UNSPECIFIEDCoins for Alzheimer's Research Trusthttp://dx.doi.org/10.13039/100012513
R01AG048108National Institute on Aginghttp://dx.doi.org/10.13039/100000049
R01AG059867National Institute on Aginghttp://dx.doi.org/10.13039/100000049
K24AG031155National Institute on Aginghttp://dx.doi.org/10.13039/100000049
R01AG026720National Institute on Aginghttp://dx.doi.org/10.13039/100000049
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