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Connection between circadian rhythms and neurodegenerative diseases
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Leng, Yue, Musiek, Erik S., Hu, Kun, Cappuccio, Francesco and Yaffe, Kristine (2019) Connection between circadian rhythms and neurodegenerative diseases. The Lancet Neurology, 18 (3). pp. 307-318. doi:10.1016/S1474-4422(18)30461-7
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Official URL: https://doi.org/10.1016/S1474-4422(18)30461-7
Abstract
Increasingly circadian rhythms have been linked to age-related diseases. We provide an up-to- date review (2013-2018) of the association between circadian rhythm disruptions (CRD) and the most common types of neurodegenerative diseases, including Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease (PD). CRD differ according to type and severity of neurodegenerative diseases, and importantly, could occur early during the course of neurodegeneration as a prodrome. Evolving evidence also supports CRD as a potential risk factor for developing ADRD and PD, although confirmatory studies are needed. Proposed mechanistic pathways underlying this association include alterations in sleep, protein homeostasis, and immune and inflammatory function. While promising, more studies of CRD and treatment trials are needed to determine whether circadian interventions may prevent or delay the onset of neurodegenerative diseases. The study of circadian rhythms holds great promise for a role in the prevention and management of neurodegenerative diseases.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||||||||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Nervous system -- Degeneration, Circadian rhythms | ||||||||||||||||||||||||
| Journal or Publication Title: | The Lancet Neurology | ||||||||||||||||||||||||
| Publisher: | The Lancet Publishing Group | ||||||||||||||||||||||||
| ISSN: | 1474-4422 | ||||||||||||||||||||||||
| Official Date: | March 2019 | ||||||||||||||||||||||||
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| Volume: | 18 | ||||||||||||||||||||||||
| Number: | 3 | ||||||||||||||||||||||||
| Page Range: | pp. 307-318 | ||||||||||||||||||||||||
| DOI: | 10.1016/S1474-4422(18)30461-7 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
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