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Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers
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Stubbs, Christopher, Congdon, Thomas R. and Gibson, Matthew I. (2019) Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers. European Polymer Journal, 110 . pp. 330-336. doi:10.1016/j.eurpolymj.2018.11.047 ISSN 0014-3057.
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WRAP-photo-polymerisation-ice-recrystallisation-hydrophobically-poly-vinyl pyrrolidone-Gibson-2019.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1802Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.eurpolymj.2018.11.047
Abstract
Antifreeze, ice binding and ice nucleating proteins modulate the formation and growth of ice in biological systems, enabling extremophiles to survive in sub-zero temperatures. A common feature is their rigidity, and segregated hydrophobic and hydrophilic domains. It has been demonstrated that increased hydrophobicity in rigid, facially amphipathic, synthetic polymers enhances ice recrystallisation inhibition (IRI) activity, but has not been evaluated in flexible systems. Here photochemical RAFT/MADIX polymerisation is used to obtain well-defined poly(N-vinyl pyrrolidone), PVP, copolymers to probe the impact of hydrophobicity on ice recrystallisation inhibition in a fully flexible polymer system, to increase the understanding on how to mimic antifreeze proteins. It is observed that PVP homopolymers have only very weak, molecular weight dependent, IRI and that hydrophobic co-monomers give very modest changes in IRI, demonstrating that the spacial segregation of ‘philicities’ is crucial, and not just the overall hydrophobic content of the polymer. These results will help design the next generation of IRI active polymers for cryopreservation applications as well as aid our understanding of how biomacromolecules can inhibit ice growth.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Antifreeze proteins, Copolymers, Crystallization, Photochemistry | |||||||||
Journal or Publication Title: | European Polymer Journal | |||||||||
Publisher: | Elsevier | |||||||||
ISSN: | 0014-3057 | |||||||||
Official Date: | 1 January 2019 | |||||||||
Dates: |
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Volume: | 110 | |||||||||
Page Range: | pp. 330-336 | |||||||||
DOI: | 10.1016/j.eurpolymj.2018.11.047 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 5 December 2018 | |||||||||
Date of first compliant Open Access: | 30 May 2020 | |||||||||
RIOXX Funder/Project Grant: |
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