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Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis

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Méric, Guillaume, Mageiros, Leonardos, Pensar, Johan, Laabei, Maisem, Yahara, Koji, Pascoe, Ben, Kittiwan, Nattinee, Tadee, Phacharaporn, Post, Virginia, Lamble, Sarah et al.
(2018) Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis. Nature Communications, 9 (1). 5034 . doi:10.1038/s41467-018-07368-7

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Official URL: http://dx.doi.org/10.1038/s41467-018-07368-7

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Abstract

Some of the most common infectious diseases are caused by bacteria that naturally colonise humans asymptomatically. Combating these opportunistic pathogens requires an understanding of the traits that differentiate infecting strains from harmless relatives. Staphylococcus epidermidis is carried asymptomatically on the skin and mucous membranes of virtually all humans but is a major cause of nosocomial infection associated with invasive procedures. Here we address the underlying evolutionary mechanisms of opportunistic pathogenicity by combining pangenome-wide association studies and laboratory microbiology to compare S. epidermidis from bloodstream and wound infections and asymptomatic carriage. We identify 61 genes containing infection-associated genetic elements (k-mers) that correlate with in vitro variation in known pathogenicity traits (biofilm formation, cell toxicity, interleukin-8 production, methicillin resistance). Horizontal gene transfer spreads these elements, allowing divergent clones to cause infection. Finally, Random Forest model prediction of disease status (carriage vs. infection) identifies pathogenicity elements in 415 S. epidermidis isolates with 80% accuracy, demonstrating the potential for identifying risk genotypes pre-operatively.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Staphylococcal infections, Staphylococcus -- Genetics, Communicable diseases -- Microbiology, Communicable diseases -- Prevention, Nosocomial infections
Journal or Publication Title: Nature Communications
Publisher: Nature Publishing Group
ISSN: 2041-1723
Official Date: 28 November 2018
Dates:
DateEvent
28 November 2018Published
23 October 2018Accepted
Volume: 9
Number: 1
Article Number: 5034
DOI: 10.1038/s41467-018-07368-7
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/L015080/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/M501608/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G0801929[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
BB/I02464X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100010269
HF-14-13National Institute for Social Care and Health Researchhttp://dx.doi.org/10.13039/100009250
UNSPECIFIED[JSPS] Japan Society for the Promotion of Sciencehttp://dx.doi.org/10.13039/501100001691
742158H2020 Excellent Sciencehttp://dx.doi.org/10.13039/100010662
UNSPECIFIEDDamp-StiftungUNSPECIFIED

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