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Data for Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers
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Stubbs, Christopher, Congdon, Thomas R. and Gibson, Matthew I. (2019) Data for Photo-polymerisation and study of the ice recrystallisation inhibition of hydrophobically modified poly(vinyl pyrrolidone) co-polymers. [Dataset]
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Dataset 111769 WRAP.zip - Unspecified Version Available under License Creative Commons: Attribution-No Derivative Works 4.0. Download (117Mb) |
Official URL: http://wrap.warwick.ac.uk/111769
Abstract
Antifreeze, ice binding and ice nucleating proteins modulate the formation and growth of ice in biological systems, enabling extremophiles to survive in sub-zero temperatures. A common feature is their rigidity, and segregated hydrophobic and hydrophilic domains. It has been demonstrated that increased hydrophobicity in rigid, facially amphipathic, synthetic polymers enhances ice recrystallisation inhibition (IRI) activity, but has not been evaluated in flexible systems. Here photochemical RAFT/MADIX polymerisation is used to obtain well-defined poly(N-vinyl pyrrolidone), PVP, copolymers to probe the impact of hydrophobicity on ice recrystallisation inhibition in a fully flexible polymer system, to increase the understanding on how to mimic antifreeze proteins. It is observed that PVP homopolymers have only very weak, molecular weight dependent, IRI and that hydrophobic co-monomers give very modest changes in IRI, demonstrating that the spacial segregation of ‘philicities’ is crucial, and not just the overall hydrophobic content of the polymer. These results will help design the next generation of IRI active polymers for cryopreservation applications as well as aid our understanding of how biomacromolecules can inhibit ice growth.
Item Type: | Dataset | |||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Type of Data: | Tabular | |||||||||
Library of Congress Subject Headings (LCSH): | Antifreeze proteins, Copolymers, Crystallization, Photochemistry | |||||||||
Journal or Publication Title: | European Polymer Journal | |||||||||
Publisher: | University of Warwick, Department of Chemistry | |||||||||
ISSN: | 0014-3057 | |||||||||
Official Date: | 1 January 2019 | |||||||||
Dates: |
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Volume: | 110 | |||||||||
Page Range: | pp. 330-336 | |||||||||
DOI: | 10.1016/j.eurpolymj.2018.11.047 | |||||||||
Status: | Not Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Media of Output (format): | .txt ..pdf .xlsx .opju | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Copyright Holders: | University of Warwick | |||||||||
Description: | All Polymer characterisation data (GPC and NMR) can be found within the Polymer Characterisation file. This includes Conversion NMRs and the origin files for the IR shown in the paper. Files are named as per the names in the paper. The CTA Characterisation(13C and 1H NMR) is found in the CTA characterisation files. IRI Assay Data contains the Data for the Splat assays used in this paper, with the average MGS and Standard deviation reported. |
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Date of first compliant deposit: | 5 December 2018 | |||||||||
RIOXX Funder/Project Grant: |
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