UNSPECIFIED (2002) Total cortisol levels are reduced in the periovulatory follicle of infertile women with minimal-mild endometriosis. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 47 (1). pp. 52-56. ISSN 8755-8920

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Abstract

PROBLEM: To measure and compare concentrations of total and free glucocorticoids with oocyte fertilizing capacity in the follicular fluid (FF) of women with minimal-mild endometriosis and tubal damage. METHOD OF STUDY: Follicular fluid was collected from individual periovulatory follicles during oocyte retrieval for in vitro fertilization (IVF) in natural cycles. Total and free levels of cortisol and cortisone were measured using specific radioimmunoassays after chloroform extraction. RESULTS: Cortisol concentrations in women with minimal-mild endometriosis were significantly lower compared with controls (women with tubal infective damage) (258 versus 328 nmol/L, P < 0.02). There was no correlation between total or free concentrations of cortisol or cortisone and the fertilization capacity of the oocyte. CONCLUSIONS: Total cortisol levels are lower in the follicles of women with endometriosis. Our findings provide further evidence of follicular dysfunction contributing to the subfertility associated with minimal-mild endometriosis.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RG Gynecology and obstetrics
Journal or Publication Title:	AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Publisher:	BLACKWELL MUNKSGAARD
ISSN:	8755-8920
Date:	January 2002
Volume:	47
Number:	1
Number of Pages:	5
Page Range:	pp. 52-56
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/11224

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