UNSPECIFIED. (2002) On the determinants of population structure in antigenically diverse pathogens. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 269 (1488). pp. 227-233. ISSN 0962-8452

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Abstract

Many pathogens exhibit antigenic diversity and elicit strain-specific immune responses. This potential for cross-immunity structure in the host resource motivates the development of mathematical models, stressing competition for susceptible hosts in driving pathogen population dynamics and genetics. Here we establish that certain model formulations exhibit characteristics of prototype pattern-forming systems, with pathogen population structure emerging as three possible patterns: (i) incidence is steady and homogeneous; (ii) incidence is steady but heterogeneous; and (iii) incidence shows oscillatory dynamics, with travelling waves in strain-space. Results are robust to strain number, but sensitive to the mechanism of cumulative immunity.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Publisher:	ROYAL SOC LONDON
ISSN:	0962-8452
Date:	7 February 2002
Volume:	269
Number:	1488
Number of Pages:	7
Page Range:	pp. 227-233
Identification Number:	10.1098/rspb.2001.1869
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/11243

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