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THz in vivo measurements : the effects of pressure on skin reflectivity
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Wang, Jiarui, Stantchev, Rayko I., Sun, Qiushuo, Chiu, Tor-Wo, Ahuja, Anil T. and Pickwell-MacPherson, Emma (2018) THz in vivo measurements : the effects of pressure on skin reflectivity. Biomedical Optics Express, 9 (12). pp. 6467-6476. doi:10.1364/BOE.9.006467
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WRAP-THz-in-vivo-measurements-pressure-skin-reflectivity-MacPherson-2018.pdf - Accepted Version - Requires a PDF viewer. Download (833Kb) | Preview |
Official URL: http://dx.doi.org/10.1364/BOE.9.006467
Abstract
Terahertz (THz) light is non-ionizing and highly sensitive to subtle changes in water concentration which can be indicative of disease. The short THz penetration depth in bio-samples restricts in vivo measurements to be in a reflection geometry and the sample is often placed onto an imaging window. Upon contacting the imaging window, occlusion and compression of the skin affect the THz response. If not appropriately controlled, this could cause misleading results. In this work, we investigate and quantify how the applied pressure affects the THz response of skin and employ a stratified model to help understand the mechanisms at play. This work will enable future THz studies to have a more rigorous experimental protocol, which in turn will facilitate research in various potential biomedical applications under investigation.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QM Human anatomy T Technology > TK Electrical engineering. Electronics Nuclear engineering |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Skin -- Research, Terahertz technology | ||||||||||||||||||
| Journal or Publication Title: | Biomedical Optics Express | ||||||||||||||||||
| Publisher: | Optical Society of America | ||||||||||||||||||
| ISSN: | 2156-7085 | ||||||||||||||||||
| Official Date: | 2018 | ||||||||||||||||||
| Dates: |
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| Volume: | 9 | ||||||||||||||||||
| Number: | 12 | ||||||||||||||||||
| Page Range: | pp. 6467-6476 | ||||||||||||||||||
| DOI: | 10.1364/BOE.9.006467 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | The Author(s) agree that all copies of the Work made under any of the above rights shall prominently include the following copyright notice: “© 2019 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.” | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Copyright Holders: | 2018 Optical Society of America | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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