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THz in vivo measurements : the effects of pressure on skin reflectivity

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Wang, Jiarui, Stantchev, Rayko I., Sun, Qiushuo, Chiu, Tor-Wo, Ahuja, Anil T. and Pickwell-MacPherson, Emma (2018) THz in vivo measurements : the effects of pressure on skin reflectivity. Biomedical Optics Express, 9 (12). pp. 6467-6476. doi:10.1364/BOE.9.006467 ISSN 2156-7085.

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Official URL: http://dx.doi.org/10.1364/BOE.9.006467

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Abstract

Terahertz (THz) light is non-ionizing and highly sensitive to subtle changes in water concentration which can be indicative of disease. The short THz penetration depth in bio-samples restricts in vivo measurements to be in a reflection geometry and the sample is often placed onto an imaging window. Upon contacting the imaging window, occlusion and compression of the skin affect the THz response. If not appropriately controlled, this could cause misleading results. In this work, we investigate and quantify how the applied pressure affects the THz response of skin and employ a stratified model to help understand the mechanisms at play. This work will enable future THz studies to have a more rigorous experimental protocol, which in turn will facilitate research in various potential biomedical applications under investigation.

Item Type: Journal Article
Subjects: Q Science > QM Human anatomy
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science, Engineering and Medicine > Science > Physics
Library of Congress Subject Headings (LCSH): Skin -- Research, Terahertz technology
Journal or Publication Title: Biomedical Optics Express
Publisher: Optical Society of America
ISSN: 2156-7085
Official Date: 2018
Dates:
DateEvent
2018Published
8 November 2018Accepted
Volume: 9
Number: 12
Page Range: pp. 6467-6476
DOI: 10.1364/BOE.9.006467
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): The Author(s) agree that all copies of the Work made under any of the above rights shall prominently include the following copyright notice: “© 2019 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.”
Access rights to Published version: Restricted or Subscription Access
Copyright Holders: 2018 Optical Society of America
Date of first compliant deposit: 15 January 2019
Date of first compliant Open Access: 17 January 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
14206717 Research Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920
14201415Research Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920
ITS/371/16Innovation and Technology Fundhttp://dx.doi.org/10.13039/501100010428
UNSPECIFIED[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
Hong Kong PhD Fellowship AwardResearch Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920

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