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Transgressive segregation reveals mechanisms of Arabidopsis immunity to Brassica-infecting races of white rust (Albugo candida)

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Cevik, Volkan, Boutrot, Freddy, Apel, Wiebke, Robert-Seilaniantz, Alexandre, Furzer, Oliver J., Redkar, Amey, Castel, Baptiste, Kover, Paula, Prince, David C., Holub, E. B. and Jones, Jonathan D. G. (2019) Transgressive segregation reveals mechanisms of Arabidopsis immunity to Brassica-infecting races of white rust (Albugo candida). Proceedings of the National Academy of Sciences, 116 (7). pp. 2767-2773. doi:10.1073/pnas.1812911116

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Official URL: https://doi.org/10.1073/pnas.1812911116

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Abstract

Arabidopsis thaliana accessions are universally resistant at the adult leaf stage to white rust (Albugo candida) races that infect the crop species Brassica juncea and Brassica oleracea. We used transgressive segregation in recombinant inbred lines to test if this apparent species-wide (nonhost) resistance in A. thaliana is due to natural pyramiding of multiple Resistance (R) genes. We screened 593 inbred lines from an Arabidopsis multiparent advanced generation intercross (MAGIC) mapping population, derived from 19 resistant parental accessions, and identified two transgressive segregants that are susceptible to the pathogen. These were crossed to each MAGIC parent, and analysis of resulting F2 progeny followed by positional cloning showed that resistance to an isolate of A. candida race 2 (Ac2V) can be explained in each accession by at least one of four genes encoding nucleotide-binding, leucine-rich repeat (NLR) immune receptors. An additional gene was identified that confers resistance to an isolate of A. candida race 9 (AcBoT) that infects B. oleracea. Thus, effector-triggered immunity conferred by distinct NLR-encoding genes in multiple A. thaliana accessions provides species-wide resistance to these crop pathogens.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Q Science > QR Microbiology
S Agriculture > SB Plant culture
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Arabidopsis thaliana, Arabidopsis thaliana -- Diseases and pests, Oomycetes, Albugo candida, Albugo candida -- Detection, Natural immunity, Cruciferae, Cruciferae -- Diseases and pests
Journal or Publication Title: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
ISSN: 0027-8424
Official Date: February 2019
Dates:
DateEvent
February 2019Published
12 February 2019Available
19 December 2018Accepted
Volume: 116
Number: 7
Page Range: pp. 2767-2773
DOI: 10.1073/pnas.1812911116
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
GBMF4725Gordon and Betty Moore Foundationhttp://dx.doi.org/10.13039/100000936
Advanced InvestigatorGrant 233376 (ALBUGON)European Research Councihttp://id.loc.gov/authorities/names/n90629676
B/L011646/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M003809/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
Long-Term Fellowship ALTF-842-2015European Molecular Biology Organizationhttp://dx.doi.org/10.13039/100004410

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