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Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

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Cheng, Wei, Rolls, Edmund T., Robbins, Trevor W., Gong, Weikang, Liu, Zhaowen, Lv, Wujun, Du, Jingnan, Wen, Hongkai, Ma, Liang, Quinlan, Erin Burke, Garavan, Hugh, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Smolka, Michael N., Schumann, Gunter, Kendrick, Keith and Feng, Jianfeng (2019) Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. eLife, 8 . e40765. doi:10.7554/elife.40765

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Official URL: https://doi.org/10.7554/eLife.40765.001

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Abstract

In a group of 831 participants from the general population in the Human Connectome Project, smokers exhibited low overall functional connectivity, and more specifically of the lateral orbitofrontal cortex which is associated with non-reward mechanisms, the adjacent inferior frontal gyrus, and the precuneus. Participants who drank a high amount had overall increases in resting state functional connectivity, and specific increases in reward-related systems including the medial orbitofrontal cortex and the cingulate cortex. Increased impulsivity was found in smokers, associated with decreased functional connectivity of the non-reward-related lateral orbitofrontal cortex; and increased impulsivity was found in high amount drinkers, associated with increased functional connectivity of the reward-related medial orbitofrontal cortex. The main findings were cross-validated in an independent longitudinal dataset with 1176 participants, IMAGEN. Further, the functional connectivities in 14-year-old non-smokers (and also in female low-drinkers) were related to who would smoke or drink at age 19. An implication is that these differences in brain functional connectivities play a role in smoking and drinking, together with other factors.

Item Type: Journal Article
Subjects: H Social Sciences > HV Social pathology. Social and public welfare
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science > Computer Science
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Cigarette smokers, Alcoholics, Addicts, Neurosciences
Journal or Publication Title: eLife
Publisher: eLife Sciences Publications, Ltd
ISSN: 2050-084X
Official Date: 17 January 2019
Dates:
DateEvent
17 January 2019Published
8 January 2019Available
20 December 2018Accepted
Volume: 8
Page Range: e40765
DOI: 10.7554/elife.40765
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Copyright Holders: © 2019, Cheng et al.
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
15JC1400101Science and Technology Commission of Shanghai Municipalityhttp://dx.doi.org/10.13039/501100003399
16JC1420402Science and Technology Commission of Shanghai Municipalityhttp://dx.doi.org/10.13039/501100003399
71661167002[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
91630314[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
UNSPECIFIEDShanghai AI Platform for Diagnosis and Treatment of Brain DiseasesUNSPECIFIED
2016–17Projects of Zhangjiang Hi-Tech District Management Committee, Shanghai UNSPECIFIED
B18015 Base for Introducing Talents of Discipline to UniversitiesUNSPECIFIED
81701773[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
11771010[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
17YF1426200Shanghai Universityhttp://dx.doi.org/10.13039/501100009002
2017M610226Research Fund for the Doctoral Program of Higher Education of ChinaUNSPECIFIED
18ZR1404400Natural Science Foundation of Shanghaihttp://dx.doi.org/10.13039/100007219
SHM-CT-2007–037286Sixth Framework Programmehttp://dx.doi.org/10.13039/100011103
695313H2020 European Research Councilhttp://dx.doi.org/10.13039/100010663
PR-ST-0416–10004European Research Area Network on Illicit Drugs (ERANID)UNSPECIFIED
MR/N027558/1Brain Imaging, cognition Dementia and next generation GEnomics (BRIDGET)UNSPECIFIED
602450Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
603016Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
115300–2 European Autism Interventions - A Multicentre Study for Developing New Medications (EU-AIMS)UNSPECIFIED
MR/N000390/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
FORMASVetenskapsrådethttp://dx.doi.org/10.13039/501100004359
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDSouth London and Maudsley NHS Foundation Trusthttp://dx.doi.org/10.13039/100009362
UNSPECIFIEDKings College Londonhttp://dx.doi.org/10.13039/501100000764
01GS08152Bundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
01EV0711Bundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
eMED SysAlc01Z x 1311ABundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
Forschungsnetz AERIABundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
SM 80/7–1, SM 80/7–2, SFB 940/1[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
AF12-NEUR0008-01-WM2NA[ANR] Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
ANR-12-SAMA-0004[ANR] Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
UNSPECIFIEDFondation de Francehttp://dx.doi.org/10.13039/501100004431
UNSPECIFIEDFondation pour la Recherche Médicalehttp://dx.doi.org/10.13039/501100002915
UNSPECIFIEDMission Interministérielle de Lutte Contre les Drogues et les Conduites AddictivesUNSPECIFIED
UNSPECIFIEDAssistance publique-Hôpitaux de ParisUNSPECIFIED
IDEX 201Université Paris-Sudhttp://dx.doi.org/10.13039/501100007486
UNSPECIFIEDNational Institutes of Healthhttp://dx.doi.org/10.13039/100000002
16/ERCD/3797Science Foundation Irelandhttp://dx.doi.org/10.13039/501100001602
RO1 MH085772-01A1National Institute of Mental Healthhttp://dx.doi.org/10.13039/100000025
U54 EB02040National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
Related URLs:
  • http://creativecommons.org/licenses/by/4...
Contributors:
ContributionNameContributor ID
UNSPECIFIEDJohansen-Berg, HeidiUNSPECIFIED
UNSPECIFIEDIvry, Richard B.UNSPECIFIED

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