Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

The transcription factor cSox2 and neuropeptide Y define a novel subgroup of amacrine cells in the retina

Tools
- Tools
+ Tools

UNSPECIFIED (2002) The transcription factor cSox2 and neuropeptide Y define a novel subgroup of amacrine cells in the retina. JOURNAL OF ANATOMY, 200 (1). pp. 51-56. ISSN 0021-8782.

Research output not available from this repository.

Request-a-Copy directly from author or use local Library Get it For Me service.

Request Changes to record.

Abstract

The retina has been extensively used as a model to study the mechanisms responsible for the production of different neural cell phenotypes. The importance of both extrinsic and intrinsic cues in these processes is now appreciated and numerous transcription factors have been identified which are required for both neuronal determination and cell differentiation. In this study we have analysed the expression of the transcription factor Sox2 during development of the chick retina. Expression was found in the proliferating cells of the retina during development and was down regulated by nearly all cell types as they started to differentiate and migrate to the different layers of the retina. In one cell type, however, Sox2 expression was retained after the cells have ceased division and migrated to their adult location. These cells formed two rows located on either side of the inner plexiform layer and were also positive for Neuropepticle Y, characteristics which indicate that they were a subpopulation of amacrine cells. The expression of Sox2 by only this population of post-mitotic neurones makes it possible to follow these cells as they migrate to their adult location and shows that they initially form a single row of cells which subsequently divides to form the double row seen in the adult tissue. We suggest that retained expression of Sox2 is involved in directing the differentiation of these cells and is an early marker of this cell type.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
Journal or Publication Title: JOURNAL OF ANATOMY
Publisher: BLACKWELL PUBLISHING LTD
ISSN: 0021-8782
Official Date: January 2002
Dates:
DateEvent
January 2002UNSPECIFIED
Volume: 200
Number: 1
Number of Pages: 6
Page Range: pp. 51-56
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us