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Synthesis and reactivity of a bis-strained alkyne derived from 1,1'-biphenyl-2,2',6,6'-tetrol
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Knighton, Richard C., Sharma, Krishna, Robertson, Naomi S., Spring, David R. and Wills, Martin (2019) Synthesis and reactivity of a bis-strained alkyne derived from 1,1'-biphenyl-2,2',6,6'-tetrol. ACS Omega, 4 (1). pp. 2160-2167. doi:10.1021/acsomega.8b03634 ISSN 2470-1343.
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Official URL: https://doi.org/10.1021/acsomega.8b03634
Abstract
Strained alkynes, i.e., alkynes distorted from the ideal linear geometry, undergo cycloaddition reactions with azides without the requirement for a copper catalyst (Scheme 1), in processes commonly referred to as strain-promoted azide-alkyne cycloaddition or “click” reactions.(1) As such, their reactions are clean and require minimal processing during a workup. Moreover, due to their bioorthogonal nature, strained alkynes have established themselves as valuable reagents for bioconjugation reactions,(2) for example, the attachment of fluorescent groups to proteins to track the protein’s movement during biological processes. Important examples of strained alkynes that have become commercially available are shown in Figure 1.(3)
Item Type: | Journal Article | ||||||||||||||||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||||||||
Journal or Publication Title: | ACS Omega | ||||||||||||||||||||||||
Publisher: | American Chemical Society | ||||||||||||||||||||||||
ISSN: | 2470-1343 | ||||||||||||||||||||||||
Official Date: | 31 January 2019 | ||||||||||||||||||||||||
Dates: |
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Volume: | 4 | ||||||||||||||||||||||||
Number: | 1 | ||||||||||||||||||||||||
Page Range: | pp. 2160-2167 | ||||||||||||||||||||||||
DOI: | 10.1021/acsomega.8b03634 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
Date of first compliant deposit: | 24 January 2019 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 30 January 2019 | ||||||||||||||||||||||||
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