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Secondary self-assembly of supramolecular nanotubes into tubisomes and their activity on cells

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Brendel, Johannes C., Sanchis, Joaquin, Catrouillet, Sylvain, Czuba, Ewa, Chen, Moore Z., Long, Benjamin M., Nowell, Cameron, Johnston, Angus P. R., Jolliffe, Katrina A. and Perrier, Sébastien (2018) Secondary self-assembly of supramolecular nanotubes into tubisomes and their activity on cells. Angewandte Chemie International Edition, 57 (51). pp. 16678-16682. doi:10.1002/anie.201808543 ISSN 1433-7851.

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Official URL: http://dx.doi.org/10.1002/anie.201808543

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Abstract

The properties and structures of viruses are directly related to the three‐dimensional structure of their capsid proteins, which arises from a combination of hydrophobic and supramolecular interactions, such as hydrogen bonds. The design of synthetic materials demonstrating similar synergistic interactions still remains a challenge. Herein, we report the synthesis of a polymer/cyclic peptide conjugate that combines the capability to form supramolecular nanotubes via hydrogen bonds with the properties of an amphiphilic block copolymer. The analysis of aqueous solutions by scattering and imaging techniques revealed a barrel‐shaped alignment of single peptide nanotubes into a large tubisome (length: 260 nm (from SANS)) with a hydrophobic core (diameter: 16 nm) and a hydrophilic shell. These systems, which have a structure that is similar to those of viruses, were tested in vitro to elucidate their activity on cells. Remarkably, the rigid tubisomes are able to perforate the lysosomal membrane in cells and release a small molecule into the cytosol.

Item Type: Journal Article
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Cyclic peptides , Nanotubes , Supramolecular chemistry
Journal or Publication Title: Angewandte Chemie International Edition
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 1433-7851
Official Date: 17 December 2018
Dates:
DateEvent
17 December 2018Published
1 November 2018Available
1 November 2018Accepted
Volume: 57
Number: 51
Page Range: pp. 16678-16682
DOI: 10.1002/anie.201808543
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): "This is the peer reviewed version of the following article:J. C. Brendel, J. Sanchis, S. Catrouillet, E. Czuba, M. Z. Chen, B. M. Long, C. Nowell, A. Johnston, K. A. Jolliffe, S. Perrier, Angew. Chem. Int. Ed. 2018, 57, 16678. which has been published in final form at http://dx.doi.org/10.1002/anie.201808543. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 24 January 2019
Date of first compliant Open Access: 1 November 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
WM130055[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
WM130055Wolfson Foundationhttp://dx.doi.org/10.13039/501100001320
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
UNSPECIFIEDMonash Universityhttp://dx.doi.org/10.13039/501100001779
TUSUPO 647106European Research CouncilUNSPECIFIED
BR 4905/1-1[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659

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