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An Arabidopsis thaliana leucine-rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens

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Bianchet, Chantal, Wong, Aloysius, Quaglia, Mara, Alqurashi, May, Gehring, Chris, Ntoukakis, Vardis and Pasqualini, Stefania (2019) An Arabidopsis thaliana leucine-rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens. Journal of Plant Physiology, 232 . pp. 12-22. doi:10.1016/j.jplph.2018.10.025

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Official URL: http://dx.doi.org/10.1016/j.jplph.2018.10.025

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Abstract

Adenylyl cyclases (ACs) catalyze the formation of the second messenger cAMP from ATP. Here we report the characterization of an Arabidopsis thaliana leucine-rich repeat (LRR) protein (At3g14460; AtLRRAC1) as an adenylyl cyclase. Using an AC-specific search motif supported by computational assessments of protein models we identify an AC catalytic center within the N-terminus and demonstrate that AtLRRAC1 can generate cAMP in vitro. Knock-out mutants of AtLRRAC1 have compromised immune responses to the biotrophic fungus Golovinomyces orontii and the hemibiotrophic bacteria Pseudomonas syringae, but not against the necrotrophic fungus Botrytis cinerea. These findings are consistent with a role of cAMP-dependent pathways in the defense against biotrophic and hemibiotrophic plant pathogens.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Q Science > QP Physiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Adenylate cyclase, Arabidopsis thaliana, Botrytis cinerea, Pseudomonas syringae
Journal or Publication Title: Journal of Plant Physiology
Publisher: Elsevier Science BV
ISSN: 0176-1617
Official Date: January 2019
Dates:
DateEvent
January 2019Published
3 November 2018Available
30 October 2018Accepted
Volume: 232
Page Range: pp. 12-22
DOI: 10.1016/j.jplph.2018.10.025
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDKing Abdullah University of Science and Technologyhttp://dx.doi.org/10.13039/501100004052
UNSPECIFIED[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
BB/L019345/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M017982/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDUniversità degli Studi di Perugiahttp://dx.doi.org/10.13039/501100010607

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