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Data for Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans
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Tomás, Ruben M. F., Martyn, Benjamin T., Bailey, Trisha L. and Gibson, Matthew I. (2018) Data for Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans. [Dataset]
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Abstract
Re-engineering mammalian cell surfaces enables modulation of their phenotype, function, and interactions with external markers and may find application in cell-based therapies. Here we use metabolic glycan labeling to install azido groups onto the cell surface, which can act as anchor points to enable rapid, simple, and robust “click” functionalization by the addition of a polymer bearing orthogonally reactive functionality. Using this strategy, new cell surface functionality was introduced by using telechelic polymers with fluorescence or biotin termini, demonstrating that recruitment of biomacromolecules is possible. This approach may enable the attachment of payloads and modulation of cell function and fate, as well as providing a tool to interface synthetic polymers with biological systems.
| Item Type: | Dataset | ||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science > Chemistry Faculty of Medicine > Warwick Medical School |
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| Type of Data: | Tabular | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cell membranes, Polymers, Cellular therapy | ||||||||||||||||||
| Journal or Publication Title: | ACS Macro Letters | ||||||||||||||||||
| Publisher: | University of Warwick / American Chemical Society | ||||||||||||||||||
| ISSN: | 2161-1653 | ||||||||||||||||||
| Official Date: | 10 October 2018 | ||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 6 November 2018 | ||||||||||||||||||
| Volume: | 2018 | ||||||||||||||||||
| Number: | 7 | ||||||||||||||||||
| Page Range: | pp. 1289-1294 | ||||||||||||||||||
| DOI: | 10.1021/acsmacrolett.8b00675 | ||||||||||||||||||
| Status: | Not Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Media of Output: | .docx | ||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||
| Description: | Data. File Excel spreadsheet containing raw data for all figures. Tabs in spreadsheet indicate the type of data, along with headings |
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| RIOXX Funder/Project Grant: |
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