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Data for Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans

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Tomás, Ruben M. F., Martyn, Benjamin T., Bailey, Trisha L. and Gibson, Matthew I. (2018) Data for Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans. [Dataset]

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Abstract

Re-engineering mammalian cell surfaces enables modulation of their phenotype, function, and interactions with external markers and may find application in cell-based therapies. Here we use metabolic glycan labeling to install azido groups onto the cell surface, which can act as anchor points to enable rapid, simple, and robust “click” functionalization by the addition of a polymer bearing orthogonally reactive functionality. Using this strategy, new cell surface functionality was introduced by using telechelic polymers with fluorescence or biotin termini, demonstrating that recruitment of biomacromolecules is possible. This approach may enable the attachment of payloads and modulation of cell function and fate, as well as providing a tool to interface synthetic polymers with biological systems.

Item Type: Dataset
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Chemistry
Faculty of Medicine > Warwick Medical School
Type of Data: Tabular
Library of Congress Subject Headings (LCSH): Cell membranes, Polymers, Cellular therapy
Journal or Publication Title: ACS Macro Letters
Publisher: University of Warwick / American Chemical Society
ISSN: 2161-1653
Official Date: 10 October 2018
Dates:
DateEvent
10 October 2018Published
9 October 2018Accepted
Volume: 2018
Number: 7
Page Range: pp. 1289-1294
DOI: 10.1021/acsmacrolett.8b00675
Status: Not Peer Reviewed
Publication Status: Published
Media of Output: .docx
Access rights to Published version: Open Access
Description:

Data. File

Excel spreadsheet containing raw data for all figures.

Tabs in spreadsheet indicate the type of data, along with headings

RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
CRYOMAT 638661European Research Councilhttp://viaf.org/viaf/130022607
EP/L015307/1RT[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/M506679/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
Advanced BioImaging RTPUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
BB/M01228X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
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