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Circadian control of abscisic acid biosynthesis and signalling pathways revealed by genome-wide analysis of LHY binding targets
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Adams, Sally, Grundy, Jack, Veflingstad, Siren R., Dyer, Nigel, Hannah, Matthew, Ott, Sascha and Carré, Isabelle A. (2018) Circadian control of abscisic acid biosynthesis and signalling pathways revealed by genome-wide analysis of LHY binding targets. New Phytologist, 220 (3). pp. 893-907. doi:10.1111/nph.15415 ISSN 0028-646X.
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Official URL: http://dx.doi.org/10.1111/nph.15415
Abstract
The LATE ELONGATED HYPOCOTYL (LHY) transcription factor functions as part of the oscillatory mechanism of the Arabidopsis circadian clock. This paper reports the genome‐wide analysis of its binding targets and reveals a role in the control of abscisic acid (ABA) biosynthesis and downstream responses.
LHY directly repressed expression of 9‐cis‐epoxycarotenoid dioxygenase enzymes, which catalyse the rate‐limiting step of ABA biosynthesis. This suggested a mechanism for the circadian control of ABA accumulation in wild‐type plants. Consistent with this hypothesis, ABA accumulated rhythmically in wild‐type plants, peaking in the evening. LHY‐overexpressing plants had reduced levels of ABA under drought stress, whereas loss‐of‐function mutants exhibited an altered rhythm of ABA accumulation.
LHY also bound the promoter of multiple components of ABA signalling pathways, suggesting that it may also act to regulate responses downstream of the hormone. LHY promoted expression of ABA‐responsive genes responsible for increased tolerance to drought and osmotic stress but alleviated the inhibitory effect of ABA on seed germination and plant growth.
This study reveals a complex interaction between the circadian clock and ABA pathways, which is likely to make an important contribution to plant performance under drought and osmotic stress conditions.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QK Botany | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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| Library of Congress Subject Headings (LCSH): | Arabidopsis, Abscisic acid, Biosynthesis, Circadian rhythms | ||||||||||
| Journal or Publication Title: | New Phytologist | ||||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||||
| ISSN: | 0028-646X | ||||||||||
| Official Date: | November 2018 | ||||||||||
| Dates: |
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| Volume: | 220 | ||||||||||
| Number: | 3 | ||||||||||
| Page Range: | pp. 893-907 | ||||||||||
| DOI: | 10.1111/nph.15415 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Reuse Statement (publisher, data, author rights): | This is the peer reviewed version of the following article: Adams, S. , Grundy, J. , Veflingstad, S. R., Dyer, N. P., Hannah, M. A., Ott, S. and Carré, I. A. (2018), Circadian control of abscisic acid biosynthesis and signalling pathways revealed by genome‐wide analysis of LHY binding targets. New Phytol, 220: 893-907. doi:10.1111/nph.15415, which has been published in final form at https://doi.org/10.1111/nph.15415. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Date of first compliant deposit: | 30 January 2019 | ||||||||||
| Date of first compliant Open Access: | 7 September 2019 | ||||||||||
| RIOXX Funder/Project Grant: |
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| Open Access Version: |
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