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The toxicological application of transcriptomics and epigenomics in zebrafish and other teleosts

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Williams, T. D., Mirbahai, Leda and Chipman, J. K. (2014) The toxicological application of transcriptomics and epigenomics in zebrafish and other teleosts. Briefings in Functional Genomics, 13 (2). pp. 157-171. doi:10.1093/bfgp/elt053 ISSN 2041-2649.

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Official URL: http://dx.doi.org/10.1093/bfgp/elt053

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Abstract

Zebrafish (Danio rerio) is one of a number of teleost fish species frequently employed in toxicology. Toxico-genomics determines global transcriptomic responses to chemical exposures and can predict their effects. It has been applied successfully within aquatic toxicology to assist in chemical testing, determination of mechanisms and environmental monitoring. Moreover, the related field of toxico-epigenomics, that determines chemical-induced changes in DNA methylation, histone modifications and micro-RNA expression, is emerging as a valuable contribution to understanding mechanisms of both adaptive and adverse responses. Zebrafish has proven a useful and convenient model species for both transcriptomic and epigenetic toxicological studies. Despite zebrafish’s dominance in other areas of fish biology, alternative fish species are used extensively in toxico-genomics. The main reason for this is that environmental monitoring generally focuses on species native to the region of interest. We are starting to see advances in the integration of high-throughput screening, omics techniques and bioinformatics together with more traditional indicator endpoints that are relevant to regulators. Integration of such approaches with high-throughput testing of zebrafish embryos, leading to the discovery of adverse outcome pathways, promises to make a major contribution to ensuring the safety of chemicals in the environment.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Briefings in Functional Genomics
Publisher: Oxford University Press
ISSN: 2041-2649
Official Date: 1 March 2014
Dates:
DateEvent
1 March 2014Published
7 January 2014Available
Volume: 13
Number: 2
Page Range: pp. 157-171
DOI: 10.1093/bfgp/elt053
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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