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Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro
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Miles, Jennifer A., Machattou, Petrina, Nevin-Jones, David, Webb, Michael E., Millard, Andrew, Scanlan, David J. and Taylor, Paul C. (2019) Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro. Biochemical and Biophysical Research Communications, 510 (1). pp. 27-34. doi:10.1016/j.bbrc.2018.12.171 ISSN 0006-291X.
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Official URL: https://doi.org/10.1016/j.bbrc.2018.12.171
Abstract
Retinoic acid signalling is generally considered to be of animal origin. Recently, retinoic acid has been identified in cyanobacteria, yet no mechanism for its production has been identified. Here, we characterise for the first time a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro. Our computational studies suggest that the cyanobacterial aldehyde dehydrogenase resembles an ancestor of both eukaryotic aldehyde dehydrogenase 1 and aldehyde dehydrogenase 2. The Chlorogloeopsis fritschii aldehyde dehydrogenase described here may find applications in synthetic production of retinoic acid as well as contributing to our understanding of retinoid synthesis in cyanobacteria. [Abstract copyright: Copyright © 2018 Elsevier Inc. All rights reserved.]
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Cyanobacteria, Tretinoic | ||||||||
Journal or Publication Title: | Biochemical and Biophysical Research Communications | ||||||||
Publisher: | Elsevier | ||||||||
ISSN: | 0006-291X | ||||||||
Official Date: | 26 February 2019 | ||||||||
Dates: |
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Volume: | 510 | ||||||||
Number: | 1 | ||||||||
Page Range: | pp. 27-34 | ||||||||
DOI: | 10.1016/j.bbrc.2018.12.171 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 7 March 2019 | ||||||||
Date of first compliant Open Access: | 7 March 2019 |
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