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Reduced GLP-1 secretion at 30 minutes after a 75-g oral glucose load is observed in gestational diabetes mellitus : a prospective cohort study
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Sukumar, Nithya, Bagias, Christos, Goljan, Ilona, Weldeselassie, Yonas, Gharanei, Seley, Tan, Bee K., Holst, Jens J. and Saravanan, Ponnusamy (2018) Reduced GLP-1 secretion at 30 minutes after a 75-g oral glucose load is observed in gestational diabetes mellitus : a prospective cohort study. Diabetes, 67 (12). pp. 2650-2656. doi:10.2337/db18-0254
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WRAP-reduced-GLP-1-secretion-minutes-oral-glucose-load-Sukumar-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1076Kb) | Preview |
Official URL: http://dx.doi.org/10.2337/db18-0254
Abstract
Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes but it has not been established whether a similar impairment exists in gestational diabetes mellitus (GDM). We studied this in a prospective cohort study of pregnant women (n=144) during oral glucose tolerance test (OGTT). GLP-1, glucose and insulin were sampled at 30-minute intervals during a 2-hour 75g OGTT and indices of insulin secretion and sensitivity calculated. In a nested case-control study, women with GDM (n=19) had 12% lower total GLP-1 secretion (area under the curve; AUC) compared to age, ethnicity and gestational-age matched controls (n=19), selected from within the lowest quartile of glucose120min values in our cohort. GDM had lower GLP-1 response in the first 30 minutes (19% lower GLP-130min and 17% lower AUC0to30min) after adjustment for possible confounders. Their glucose levels began to diverge at 30 minutes of the OGTT with increasing insulin levels, and by 120 minutes, their insulin levels were three times higher. In a secondary cohort of 57 women, which included ‘high-normal’ glucose120min values, low GLP-1 AUC0to30min was independently associated with lower indices of insulin secretion and sensitivity. In conclusion, we have observed that women with GDM have lower GLP-1 response at 30 minutes of an OGTT and hyperglycaemia at 120 minutes despite significant hyperinsulinaemia.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Medicine > Warwick Medical School | ||||||
| Library of Congress Subject Headings (LCSH): | Diabetes , Diabetes in pregnancy | ||||||
| Journal or Publication Title: | Diabetes | ||||||
| Publisher: | American Diabetes Association | ||||||
| ISSN: | 0012-1797 | ||||||
| Official Date: | 19 September 2018 | ||||||
| Dates: |
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| Date of first compliant deposit: | 18 February 2019 | ||||||
| Volume: | 67 | ||||||
| Number: | 12 | ||||||
| Page Range: | pp. 2650-2656 | ||||||
| DOI: | 10.2337/db18-0254 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Publisher Statement: | This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals.org/content/67/12/2650.article-info | ||||||
| Access rights to Published version: | Open Access | ||||||
| Copyright Holders: | © 2018 by the American Diabetes Association | ||||||
| RIOXX Funder/Project Grant: |
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