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DNA as a catalyst and catalytic template for the racemisation of metal tris-phenanthroline complexes

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Rodger, Alison, Nordén, Bengt, 1945-, Rodger, P. Mark and Bates, Paula J.. (2002) DNA as a catalyst and catalytic template for the racemisation of metal tris-phenanthroline complexes. European Journal of Inorganic Chemistry, Vol.2002 (No.1). pp. 49-53. ISSN 1434-1948

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Official URL: http://dx.doi.org/10.1002/1099-0682(20021)2002:1<4...

Abstract

[Fe(1,10-phenanthroline)(3)](2+) is known to racemise in solution and DNA is known to shift the equilibrium point of the Delta/Lambda[Fe(1,10-phenanthroline)(3)](2+) mixture from 50:50 to a position favouring a slight excess of the Delta enantiomer. In this paper it is shown that DNA catalyses the racemisation reaction, presumably by providing vibrational energy to species that bind in a less favoured mode for that enantiomer. The racemisation of [Co(1,10-phenanthroline)(3)](3+), however, is not enhanced by DNA unless [Co(1,10-phenanthroline)(3)](2+) is also added to the solution. In this case, the DNA acts as a template to facilitate the Co-II reversible arrow Co-III electron transfer. Racemisation occurs while the [Co(1,10-phenanthroline)(3)](n+) is in the labile Co-II form.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Racemization, Enantiomers, DNA
Journal or Publication Title:	European Journal of Inorganic Chemistry
Publisher:	Wiley-VCH Verlag GMBH
ISSN:	1434-1948
Official Date:	January 2002
Volume:	Vol.2002
Number:	No.1
Number of Pages:	5
Page Range:	pp. 49-53
Identification Number:	10.1002/1099-0682(20021)2002:1<49::AID-EJIC49>3.0.CO;2-8
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
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URI:	http://wrap.warwick.ac.uk/id/eprint/11365