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Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles
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Wilkins, Laura E., Hasan, Muhammad, Fayter, Alice E. R., Biggs, Caroline I., Walker, Marc and Gibson, Matthew I. (2019) Site-specific conjugation of antifreeze proteins onto polymer-stabilized nanoparticles. Polymer Chemistry, 10 (23). pp. 2986-2990. doi:10.1039/c8py01719k ISSN 1759-9962.
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WRAP-site-specific-conjugation-antifreez-proteins-Gibson-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (1632Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/c8py01719k
Abstract
Antifreeze proteins (AFPs) have many potential applications, ranging from cryobiology to aerospace, if they can be incorporated into materials. Here, a range of engineered AFP mutants were prepared and site-specifically conjugated onto RAFT polymer-stabilized gold nanoparticles to generate new hybrid multivalent ice growth inhibitors. Only the SNAP-tagged AFPs lead to potent ‘antifreeze’ active nanomaterials with His-Tag capture resulting in no activity, showing the mode of conjugation is essential. This versatile strategy will enable the development of multivalent AFPs for translational and fundamental studies.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Antifreeze proteins, Nanoparticles, Ice crystals -- Growth | ||||||||||||||||||
Journal or Publication Title: | Polymer Chemistry | ||||||||||||||||||
Publisher: | Royal Society of Chemistry (RSC) | ||||||||||||||||||
ISSN: | 1759-9962 | ||||||||||||||||||
Official Date: | 21 June 2019 | ||||||||||||||||||
Dates: |
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Volume: | 10 | ||||||||||||||||||
Number: | 23 | ||||||||||||||||||
Page Range: | pp. 2986-2990 | ||||||||||||||||||
DOI: | 10.1039/c8py01719k | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Reuse Statement (publisher, data, author rights): | ** Article version: VoR ** From Crossref via Jisc Publications Router ** License for VoR version of this article starting on 31-01-2019: http://creativecommons.org/licenses/by/3.0/ | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 19 February 2019 | ||||||||||||||||||
Date of first compliant Open Access: | 19 February 2019 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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