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Terahertz microfluidic metamaterial biosensor for sensitive detection of small volume liquid samples
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Zhang, Rui, Chen, Qingming, Liu, Kai, Chen, Zefeng, Li, Kaidi, Zhang, Xuming, Xu, Jianbin and Pickwell-MacPherson, Emma (2019) Terahertz microfluidic metamaterial biosensor for sensitive detection of small volume liquid samples. IEEE Transactions on Terahertz Science and Technology . (In Press)
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Abstract
Metamaterial assisted terahertz (THz) label-free bio-sensing has promising applications. However, the sensitive THz detection of highly absorptive liquid samples remains challenging. Here, we present a novel multi-microfluidic-channel metamaterial biosensor (MMCMMB) for highly sensitive THz sensing of small volume liquid samples. The multi-channels are set mostly in the strong electric field enhancement area of the metamaterial, which significantly decreases the liquid amount and enhances interaction between the sensing targets and the THz wave (thus increasing the sensitivity). The sensing results of isopropyl alcohol (IPA)-water mixtures and bovine serum albumin (BSA) solutions based on the bow-tie array metamaterial with multi-channels demonstrate the effectiveness of this proposed design and the great potential in THz bio-sensing. This design has the advantages of being highly sensitive, label-free, cost-effective, easy to operate and only needing a tiny liquid volume. Thus our device provides a robust route for metamaterial assisted THz label-free bio-sensing of liquid-based substances.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QC Physics T Technology > TJ Mechanical engineering and machinery |
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| Divisions: | Faculty of Science > Physics | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Microfluidic devices, Terahertz spectroscopy | ||||||||||||
| Journal or Publication Title: | IEEE Transactions on Terahertz Science and Technology | ||||||||||||
| Publisher: | IEEE | ||||||||||||
| ISSN: | 2156-342X | ||||||||||||
| Official Date: | 1 February 2019 | ||||||||||||
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| Date of first compliant deposit: | 11 February 2019 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | In Press | ||||||||||||
| Publisher Statement: | © 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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