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Terahertz microfluidic metamaterial biosensor for sensitive detection of small volume liquid samples

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Zhang, Rui, Chen, Qingming, Liu, Kai, Chen, Zefeng, Li, Kaidi, Zhang, Xuming, Xu, Jianbin and Pickwell-MacPherson, Emma (2019) Terahertz microfluidic metamaterial biosensor for sensitive detection of small volume liquid samples. IEEE Transactions on Terahertz Science and Technology . (In Press)

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Abstract

Metamaterial assisted terahertz (THz) label-free bio-sensing has promising applications. However, the sensitive THz detection of highly absorptive liquid samples remains challenging. Here, we present a novel multi-microfluidic-channel metamaterial biosensor (MMCMMB) for highly sensitive THz sensing of small volume liquid samples. The multi-channels are set mostly in the strong electric field enhancement area of the metamaterial, which significantly decreases the liquid amount and enhances interaction between the sensing targets and the THz wave (thus increasing the sensitivity). The sensing results of isopropyl alcohol (IPA)-water mixtures and bovine serum albumin (BSA) solutions based on the bow-tie array metamaterial with multi-channels demonstrate the effectiveness of this proposed design and the great potential in THz bio-sensing. This design has the advantages of being highly sensitive, label-free, cost-effective, easy to operate and only needing a tiny liquid volume. Thus our device provides a robust route for metamaterial assisted THz label-free bio-sensing of liquid-based substances.

Item Type: Journal Article
Subjects: Q Science > QC Physics
T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Science > Physics
Library of Congress Subject Headings (LCSH): Microfluidic devices, Terahertz spectroscopy
Journal or Publication Title: IEEE Transactions on Terahertz Science and Technology
Publisher: IEEE
ISSN: 2156-342X
Official Date: 1 February 2019
Dates:
DateEvent
1 February 2019Accepted
Date of first compliant deposit: 11 February 2019
Status: Peer Reviewed
Publication Status: In Press
Publisher Statement: © 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
14201415Research Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920
14205514Research Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920
UNSPECIFIED[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
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