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Ethical issues in living-related corneal tissue transplantation
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Behaegel, Joséphine, Dhubhghaill, Sorcha Ní and Draper, Heather (2019) Ethical issues in living-related corneal tissue transplantation. Journal of Medical Ethics, 45 (7). pp. 430-434. doi:10.1136/medethics-2018-105146 ISSN 0306-6800.
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Official URL: http://dx.doi.org/10.1136/medethics-2018-105146
Abstract
The cornea was the first human solid tissue to be transplanted successfully, and is now a common procedure in ophthalmic surgery. The grafts come from deceased donors. Corneal therapies are now being developed that rely on tissue from living-related donors. This presents new ethical challenges for ophthalmic surgeons, who have hitherto been somewhat insulated from debates in transplantation and donation ethics. This paper provides the first overview of the ethical considerations generated by ocular tissue donation from living donors and suggests how these might be addressed in practice. These are discussed in the context of a novel treatment for corneal limbal stem cell deficiency. This involves limbal cell grafts which are transplanted, either directly or after ex vivo expansion, onto recipient stem cell-deficient eyes. Where only one eye is diseased, the unaffected eye can be used as a source of graft tissue. Bilateral disease requires an allogenic donation, preferably from a genetically related living donor. While numerous papers have dealt with the theory, surgical approaches, and clinical outcomes of limbal stem cell therapies, none have addressed the ethical dimensions of this form of tissue donation.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Medical Ethics | ||||||||
| Publisher: | BMJ Group | ||||||||
| ISSN: | 0306-6800 | ||||||||
| Official Date: | 2 August 2019 | ||||||||
| Dates: |
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| Volume: | 45 | ||||||||
| Number: | 7 | ||||||||
| Page Range: | pp. 430-434 | ||||||||
| DOI: | 10.1136/medethics-2018-105146 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 19 February 2019 | ||||||||
| Date of first compliant Open Access: | 16 August 2019 | ||||||||
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