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Starch film-coated microparticles for oral colon-specific drug delivery
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Chen, Jin, Li, Xiaoxi, Chen, Ling and Xie, Fengwei (2018) Starch film-coated microparticles for oral colon-specific drug delivery. Carbohydrate Polymers, 191 . pp. 242-254. doi:10.1016/j.carbpol.2018.03.025 ISSN 0144-8617.
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Official URL: http://dx.doi.org/10.1016/j.carbpol.2018.03.025
Abstract
The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon. An oral colon-specific controlled-release system was developed in the form of MPs coated with a resistant starch (RS2/RS3) film (RS@MPs) through an aqueous suspension coating process. The RS2 was chosen from a high-amylose cornstarch with 88.5% digestion resistibility. The RS3 was prepared by a high-temperature/pressure (HTP) treatment, with the following of enzymatic debranching, and retrogradation, resulting in a dramatic increase in enzymatic resistance (RS3 content: 76.6%). RS@MPs showed 40.7% of 5-aminosalicylic acid release within 8 h. The in vivo study of fluorescein-loaded RS@MPs indicated the high acidic and enzymatic resistibility of RS@MPs and a restrained release in the upper GIT. Therefore, RS@MPs has revealed to be a high potential system for accurately targeting bioactive compound delivery to the colon.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | R Medicine > RS Pharmacy and materia medica | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Drug delivery systems, Starch in medicine | ||||||||||||||||||
Journal or Publication Title: | Carbohydrate Polymers | ||||||||||||||||||
Publisher: | Pergamon Press | ||||||||||||||||||
ISSN: | 0144-8617 | ||||||||||||||||||
Official Date: | 1 July 2018 | ||||||||||||||||||
Dates: |
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Volume: | 191 | ||||||||||||||||||
Page Range: | pp. 242-254 | ||||||||||||||||||
DOI: | 10.1016/j.carbpol.2018.03.025 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
Date of first compliant deposit: | 8 March 2019 | ||||||||||||||||||
Date of first compliant Open Access: | 13 March 2019 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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