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Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors

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Zheng, Bo, Xie, Fengwei, Situ, Wenbei, Chen, Ling and Li, Xiaoxi (2017) Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors. Journal of Functional Foods, 37 . pp. 272-282. doi:10.1016/j.jff.2017.07.048

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Official URL: http://dx.doi.org/10.1016/j.jff.2017.07.048

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Abstract

A new carrier system for controlled release of immunologic peptides based on double polysaccharide film-coated microparticles (PCMPs) used with liquid products was developed. The release behavior of PCMPs was shown dependent on the thicknesses of the outer chitosan film and the inner resistant starch acetate (RSA) film. The in-vitro release results indicated that, with optimized polysaccharide coating thickness (RSA: 4–5%; chitosan: 6–7%), the release rate of Thymopoietin (TP5) was less than 30% before the microparticles reached the colon, and was 50% in the colon. Besides, the bioavailability of PCMPs was evaluated based on the cell proliferation and protein expression. Compared with the intraperitoneal injection or oral administration, the immunodeficient rats that were orally administrated with the yogurt containing TP5-loaded PCMPs with different storage times possessed a good colon-targeting behavior, higher ratios of CD4/CD8 and IgG expression, indicating the improvement in the TP5 immunologic function.

Item Type: Journal Article
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Divisions: Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH): Yogurt -- Therapeutic use -- Controlled release, Biomedical materials, Chitosan -- Industrial applications
Journal or Publication Title: Journal of Functional Foods
Publisher: Elsevier
ISSN: 2214-9414
Official Date: October 2017
Dates:
DateEvent
October 2017Published
22 July 2017Accepted
Volume: 37
Page Range: pp. 272-282
DOI: 10.1016/j.jff.2017.07.048
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
U1501214[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
2014YT02S029YangFan Innovative and Entrepreneurial Research Team ProjectUNSPECIFIED
2014B090904047R&D Projects of Guangdong ProvinceUNSPECIFIED
201607010109Guangzhou Municipal Science and Technology Projecthttp://dx.doi.org/10.13039/501100010256
2014A2FC217The Key R&D Projects of ZhongshanUNSPECIFIED
2015KTSCX006Universities in Guangdong ProvinceUNSPECIFIED
2015ZZ106[MEPRC] Ministry of Education of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002338

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