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Branched poly (trimethylphosphonium ethylacrylate-co-PEGA) by RAFT : alternative to cationic polyammoniums for nucleic acid complexation

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Cook, Alexander B., Peltier, Raoul, Barlow, Tammie R., Tanaka, Joji, Burns, James A. and Perrier, Sébastien (2018) Branched poly (trimethylphosphonium ethylacrylate-co-PEGA) by RAFT : alternative to cationic polyammoniums for nucleic acid complexation. Journal of Interdisciplinary Nanomedicine, 3 (4). pp. 164-174. doi:10.1002/jin2.50

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Official URL: http://dx.doi.org/10.1002/jin2.50

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Abstract

Cationic and highly branched poly (trimethylphosphonium ethylacrylate‐co‐poly (ethylene glycol) acrylate) (p (TMPEA‐co‐PEGA)), and its ammonium equivalent, have been synthesised from post‐polymerisation modification of a poly (bromo ethylacrylate‐co‐poly (ethylene glycol) acrylate) (p (BEA‐co‐PEGA)) precursor polymer produced using reversible addition fragmentation chain transfer (RAFT) polymerisation. The cationic polymers were evaluated for their ability to complex nucleic acids, their in vitro cytotoxicity and their GFP pDNA transfection efficiency. The results show RAFT copolymerisation of BEA and PEGA is a simple route to polyphosphoniums showing reduced cytotoxicities and higher transfection efficiencies than their polyammonium alternatives.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Addition polymerization, Branched polymers, Nucleic acids, Fragmentation reactions
Journal or Publication Title: Journal of Interdisciplinary Nanomedicine
Publisher: Wiley Open Access
ISSN: 2058-3273
Official Date: December 2018
Dates:
DateEvent
December 2018Published
21 December 2018Available
31 July 2018Accepted
Volume: 3
Number: 4
Page Range: pp. 164-174
DOI: 10.1002/jin2.50
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
WM130055[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
UNSPECIFIEDMonash Universityhttp://dx.doi.org/10.13039/501100001779
UNSPECIFIEDSyngenta Internationalhttp://dx.doi.org/10.13039/501100010761
TUSUPO 647106European Research Councilhttp://viaf.org/viaf/130022607
EP/F500378/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266

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