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Branched poly (trimethylphosphonium ethylacrylate-co-PEGA) by RAFT : alternative to cationic polyammoniums for nucleic acid complexation
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Cook, Alexander B., Peltier, Raoul, Barlow, Tammie R., Tanaka, Joji, Burns, James A. and Perrier, Sébastien (2018) Branched poly (trimethylphosphonium ethylacrylate-co-PEGA) by RAFT : alternative to cationic polyammoniums for nucleic acid complexation. Journal of Interdisciplinary Nanomedicine, 3 (4). pp. 164-174. doi:10.1002/jin2.50
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Official URL: http://dx.doi.org/10.1002/jin2.50
Abstract
Cationic and highly branched poly (trimethylphosphonium ethylacrylate‐co‐poly (ethylene glycol) acrylate) (p (TMPEA‐co‐PEGA)), and its ammonium equivalent, have been synthesised from post‐polymerisation modification of a poly (bromo ethylacrylate‐co‐poly (ethylene glycol) acrylate) (p (BEA‐co‐PEGA)) precursor polymer produced using reversible addition fragmentation chain transfer (RAFT) polymerisation. The cationic polymers were evaluated for their ability to complex nucleic acids, their in vitro cytotoxicity and their GFP pDNA transfection efficiency. The results show RAFT copolymerisation of BEA and PEGA is a simple route to polyphosphoniums showing reduced cytotoxicities and higher transfection efficiencies than their polyammonium alternatives.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||
| Divisions: | Faculty of Science > Chemistry | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Addition polymerization, Branched polymers, Nucleic acids, Fragmentation reactions | |||||||||||||||||||||
| Journal or Publication Title: | Journal of Interdisciplinary Nanomedicine | |||||||||||||||||||||
| Publisher: | Wiley Open Access | |||||||||||||||||||||
| ISSN: | 2058-3273 | |||||||||||||||||||||
| Official Date: | December 2018 | |||||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 26 February 2019 | |||||||||||||||||||||
| Volume: | 3 | |||||||||||||||||||||
| Number: | 4 | |||||||||||||||||||||
| Page Range: | pp. 164-174 | |||||||||||||||||||||
| DOI: | 10.1002/jin2.50 | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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