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Polymeric arsenicals as scaffolds for functional and responsive hydrogels

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Tanaka, Joji, Song, Ji-Inn, Lunn, Andrew M., Hand, Rachel A., Häkkinen, Satu, Schiller, Tara L., Perrier, Sébastien, Davis, Thomas P. and Wilson, Paul (2019) Polymeric arsenicals as scaffolds for functional and responsive hydrogels. Journal of Materials Chemistry B, 7 (27). pp. 4263-4271. doi:10.1039/C8TB02569J

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Official URL: http://dx.doi.org/10.1039/C8TB02569J

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Abstract

Here arsenohydrogels are introduced for the first time as functional, tuneable and responsive hydrogels. The distinctive redox reactivity of arsenic has been exploited to crosslink high molecular weight (Mw > 300 kDa) polymeric arsenical scaffolds (PDMAmx-co-AsAmy) via reductive coupling of As(V) to As(I) which proceeds with the formation of As–As in the form of As(I)n homocycles. Soft arsenohydrogels (G′ ∼ 400–1700 Pa) that failed in compression tests at low compression and loading are formed when the polymer weight fraction is 2.5 wt%. When the polymer weight fraction is increased to 10 wt% the mechanical properties (stiffness and relaxation) of the arsenohydrogels are significantly improved and correlate with the mole fraction of arsenic (AsAm, y) present in the copolymer scaffolds. Furthermore, increasing the mole fraction of AsAm, reduces the degree of swelling and increases the stability of the gels against hydrolysis and oxidation of the As–As crosslinks. The functionality of the polymeric arsenical scaffolds has also been exploited to load arsenohydrogels with a model organic arsenical drug. The rate and degree of release of the loaded organic arsenical under simulated oxidative stress (H2O2) is inversely proportional to the mole fraction of arsenic in the original polymer scaffold. Finally, the polymeric arsenical scaffolds and the resulting arsenohydrogels have been shown to be non-toxic to NIH/3T3 (mouse fibroblast) and PC3 (human prostate cancer) cell lines. The properties and versitility of the arsenohydrogels alludes to their potential as a functional platform for biomaterials.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Colloids, Arsenic compounds
Journal or Publication Title: Journal of Materials Chemistry B
Publisher: R S C Publications
ISSN: 2050-750X
Official Date: 21 July 2019
Dates:
DateEvent
21 July 2019Published
21 February 2019Available
15 February 2019Accepted
Volume: 7
Number: 27
Page Range: pp. 4263-4271
DOI: 10.1039/C8TB02569J
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
EP/F500378/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
UNSPECIFIEDMonash Universityhttp://dx.doi.org/10.13039/501100001779
CE140100036[ARC] Australian Research Councilhttp://dx.doi.org/10.13039/501100000923
Australian Laureate Fellowship[ARC] Australian Research Councilhttp://dx.doi.org/10.13039/501100000923
WM130055[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
URF\R1\180274[RS] Royal Societyhttp://dx.doi.org/10.13039/501100000288
ECF/2015-075Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
UNSPECIFIEDLubrizolhttp://dx.doi.org/10.13039/100007036

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