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Functional brush poly(2-ethyl-2-oxazine)s : synthesis by CROP and RAFT, thermoresponsiveness and grafting onto iron oxide nanoparticles
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Klein, Tobias, Parkin, Joshua, de Jongh, Patrick A. J. M., Esser, Lars, Sepehrizadeh, Tara, Zheng, Gang, De Veer, Michael, Alt, Karen, Hagemeyer, Christoph E., Haddleton, David M., Davis, Thomas P., Thelakkat, Mukundan and Kempe, Kristian (2019) Functional brush poly(2-ethyl-2-oxazine)s : synthesis by CROP and RAFT, thermoresponsiveness and grafting onto iron oxide nanoparticles. Macromolecular Rapid Communications, 40 (10). 1800911. doi:10.1002/marc.201800911 ISSN 1022-1336.
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WRAP-functional-brush-poly(2-ethyl-2-oxazine)s-Haddleton-2019.pdf - Accepted Version - Requires a PDF viewer. Download (1486Kb) | Preview |
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Official URL: http://dx.doi.org/10.1002/marc.201800911
Abstract
Brush polymers are highly functional polymeric materials combining the properties of different polymer classes and have found numerous applications, for example, in nanomedicine. Here, the synthesis of functional phosphonate‐ester‐bearing brush polymers based on poly(2‐oxazine)s is reported through a combination of cationic ring‐opening polymerization (CROP) of 2‐ethyl‐2‐oxazine and reversible addition‐fragmentation chain transfer (RAFT) polymerization. In this way, a small library of well‐defined (Đ ≤ 1.17) poly(oligo(2‐ethyl‐2‐oxazine) methacrylate) P(OEtOzMA)n brushes with tunable lower critical solution temperature (LCST) behavior and negligible cell toxicity is prepared. Upon deprotection, the phosphonic acid end‐group of the P(OEtOzMA)n brush enables the successful grafting‐onto iron oxide nanoparticles (IONPs). Colloidal stability of the particle suspension in combination with suitable magnetic resonance imaging (MRI) relaxivities demonstrates the potential of these particles for future applications as negative MRI contrast agents.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Fragmentation reactions, Addition polymerization | ||||||||
Journal or Publication Title: | Macromolecular Rapid Communications | ||||||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||
ISSN: | 1022-1336 | ||||||||
Official Date: | May 2019 | ||||||||
Dates: |
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Volume: | 40 | ||||||||
Number: | 10 | ||||||||
Article Number: | 1800911 | ||||||||
DOI: | 10.1002/marc.201800911 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 5 March 2019 | ||||||||
Date of first compliant Open Access: | 12 January 2020 | ||||||||
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