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Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands
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Shi, Huayun, Clarkson, Guy J. and Sadler, Peter J. (2019) Dual action photosensitive platinum(II) anticancer prodrugs with photoreleasable azide ligands. Inorganica Chimica Acta, 489 . pp. 230-235. doi:10.1016/j.ica.2019.02.016 ISSN 0020-1693.
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Official URL: http://dx.doi.org/10.1016/j.ica.2019.02.016
Abstract
The synthesis, characterisation and properties of novel photosensitive Pt(II) complexes [Pt(terpyridine)(N3)]CF3SO3 (1b∙CF3SO3) and [Pt(N^C^N)(N3)] (2b) containing photoreleasable azide ligands with potential as dual photochemotherapeutic and photodynamic therapeutic agents are reported. Their X-ray crystal structures show distorted square-planar Pt(II) coordination geometry with π-stacking between adjacent planar Pt units. These complexes intercalate into DNA with similar binding ability as their chlorido analogues and generate singlet oxygen upon irradiation with blue light (420 nm). Photoactivation of azido complexes leads to the release of the azide ligands and the formation of new platinum species. These properties appear to be favourable for potential dual-action photoactive prodrugs.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Antineoplastic agents, Azides, Ligands | |||||||||||||||
Journal or Publication Title: | Inorganica Chimica Acta | |||||||||||||||
Publisher: | Elsevier BV | |||||||||||||||
ISSN: | 0020-1693 | |||||||||||||||
Official Date: | 1 April 2019 | |||||||||||||||
Dates: |
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Volume: | 489 | |||||||||||||||
Page Range: | pp. 230-235 | |||||||||||||||
DOI: | 10.1016/j.ica.2019.02.016 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 1 March 2019 | |||||||||||||||
Date of first compliant Open Access: | 4 March 2019 | |||||||||||||||
RIOXX Funder/Project Grant: |
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