The Library
Insulin resistance and obesity, and their association with depression in relatively young people : findings from a large UK birth cohort
Tools
Tools
Tools
Perry, B. I., Khandaker, G. M., Marwaha, S., Thompson, Andrew D., Zammit, S., Singh, Swaran P. and Upthegrove, R. (2020) Insulin resistance and obesity, and their association with depression in relatively young people : findings from a large UK birth cohort. Psychological Medicine, 50 (4). pp. 556-565. doi:10.1017/S0033291719000308 ISSN 0033-2917.
|
PDF
WRAP-insulin-obesity-depression-relatively-young-people-Singh-2019.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (228Kb) | Preview |
Official URL: http://dx.doi.org/10.1017/S0033291719000308
Abstract
Background
Depression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people.
Methods
Using the Avon Longitudinal Study of Parents and Children birth cohort, we used regression analyses to examine: (1) cross-sectional and (2) longitudinal associations between measures of DGIH [insulin resistance (IR); impaired glucose tolerance] and body mass index (BMI) at ages 9 and 18 years, and depression (depressive symptoms and depressive episode) at age 18 years and (3) whether sociodemographics, lifestyle factors or inflammation [interleukin-6 (IL-6) at age 9 years] confounded any such associations.
Results
We included 3208 participants. At age 18 years, IR and BMI were positively associated with depression. These associations may be explained by sociodemographic and lifestyle factors. There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.
Conclusions
Young people with depression show evidence of DGIH and raised BMI, which may be related to sociodemographic and lifestyle effects such as deprivation, smoking, ethnicity and gender. In future, studies with larger samples are required to confirm this. Preventative strategies for the poorer physical health outcomes associated with depression should focus on malleable lifestyle factors.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Insulin resistance -- Psychological aspects -- Great Briatin, Obesity -- Psychological aspects -- Great Briatin, Depression, Mental -- Great Briatin | ||||||||||||||||||||||||||||||
| Journal or Publication Title: | Psychological Medicine | ||||||||||||||||||||||||||||||
| Publisher: | Cambridge University Press | ||||||||||||||||||||||||||||||
| ISSN: | 0033-2917 | ||||||||||||||||||||||||||||||
| Official Date: | March 2020 | ||||||||||||||||||||||||||||||
| Dates: |
|
||||||||||||||||||||||||||||||
| Volume: | 50 | ||||||||||||||||||||||||||||||
| Number: | 4 | ||||||||||||||||||||||||||||||
| Page Range: | pp. 556-565 | ||||||||||||||||||||||||||||||
| DOI: | 10.1017/S0033291719000308 | ||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||
| Copyright Holders: | © Cambridge University Press 2019 | ||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 12 March 2019 | ||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 13 March 2019 | ||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
