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Pinstatic acid promotes auxin efflux transport by inhibiting PIN internalization
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Oochi, Akihiro, Hajny, Jakub, Fukui, Kosuke, Nakao, Yukio, Gallei, Michelle, Quareshy, Mussa, Takahashi, Koji, Kinoshita, Toshinori, Ramans Harborough, Sigurd, Kepinski, Stefan, Kasahara, Hiroyuki, Napier, R. (Richard), Friml, Jiri and Hayashi, Ken-ichiro (2019) Pinstatic acid promotes auxin efflux transport by inhibiting PIN internalization. Plant Physiology, 180 (2). pp. 1152-1165. doi:10.1104/pp.19.00201 ISSN 0032-0889.
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Official URL: https://doi.org/10.1104/pp.19.00201
Abstract
Polar auxin transport plays a pivotal role in plant growth and development. PIN auxin efflux carriers are major mediators for directional auxin movement establishing local auxin maxima, minima, and gradients that drive multiple developmental processes and responses to environmental signals. Auxin has been proposed to modulate its own transport by regulating subcellular PIN trafficking, including by clathrin-mediated PIN endocytosis and recycling. The mechanism of auxin’s effect on PIN trafficking remains elusive. To dissect the regulatory mechanism of PIN trafficking by auxin, we screened auxin analogs and identified pinstatic acid (PISA) as a positive modulator of polar auxin transport. PISA shows auxin-like activity for hypocotyl elongation and adventitious root formation via positive regulation of auxin transport. PISA was inert for SCFTIR1/AFB signaling and yet induces PIN accumulation at the cell surface by inhibiting PIN internalization from the plasma membrane. PISA is thus a promising chemical tool to dissect the regulatory mechanisms of subcellular PIN trafficking and auxin transport.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Journal or Publication Title: | Plant Physiology | ||||||||
| Publisher: | American Society of Plant Biologists | ||||||||
| ISSN: | 0032-0889 | ||||||||
| Official Date: | June 2019 | ||||||||
| Dates: |
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| Volume: | 180 | ||||||||
| Number: | 2 | ||||||||
| Page Range: | pp. 1152-1165 | ||||||||
| DOI: | 10.1104/pp.19.00201 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 25 March 2019 | ||||||||
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