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Starch/microcrystalline cellulose hybrid gels as gastric-floating drug delivery systems
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Xu, Jinchuan, Tan, Xiaoyan, Chen, Ling, Li, Xiaoxi and Xie, Fengwei (2019) Starch/microcrystalline cellulose hybrid gels as gastric-floating drug delivery systems. Carbohydrate Polymers, 215 . pp. 151-159. doi:10.1016/j.carbpol.2019.03.078 ISSN 0144-8617.
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Official URL: http://dx.doi.org/10.1016/j.carbpol.2019.03.078
Abstract
We report hybrid gels based on a high-amylose starch and microcrystalline cellulose with demonstrated properties for gastric-floating drug delivery purposes. The starch/cellulose gels were prepared by ionic liquid dissolution and regeneration, resulting in a continuous surface and a porous interior and a type-II crystalline structure of cellulose. These polysaccharide gels displayed satisfactory elasticity (0.88), recovery (0.26–0.36) and equilibrium swelling (1013–1369%). The hybrid gels were loaded with ranitidine hydrochloride as a model drug and subsequently, low-density starch/cellulose tablets were fabricated by vacuum-freeze-drying. In vitro tests in a simulated gastric fluid indicate that the 3:7 (wt./wt.) starch/cellulose system could maintain the buoyancy for up to 24 h with a release of 45.87% for the first 1 h and a sustained release for up to 10 h. Therefore, our results have demonstrated the excellent gastric-floating ability and sustainable drug release behavior of the starch/cellulose hybrid gels.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Drug delivery systems, Polysaccharides, Starch -- Industrial applications, Cellulose -- Industrial applications | |||||||||||||||
Journal or Publication Title: | Carbohydrate Polymers | |||||||||||||||
Publisher: | Pergamon Press | |||||||||||||||
ISSN: | 0144-8617 | |||||||||||||||
Official Date: | 1 July 2019 | |||||||||||||||
Dates: |
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Volume: | 215 | |||||||||||||||
Page Range: | pp. 151-159 | |||||||||||||||
DOI: | 10.1016/j.carbpol.2019.03.078 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 1 April 2019 | |||||||||||||||
Date of first compliant Open Access: | 25 March 2020 | |||||||||||||||
RIOXX Funder/Project Grant: |
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